Regulating mechanism of blood pressure by the hawthorn and olive phyto- and gemmo-therapic extracts



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Article Title: Regulating mechanism of blood pressure by the hawthorn and olive phyto- and gemmo-therapic extracts
Authors: Alaya A., Olah N.K., Pripon Furtuna F.R., Burtescu R.F., Chișe E., Hepcal Cuc I.-M., Hanganu D., Bota V.B., Ivănescu L., Ungureanu O., Arsene G.-G., Turcuș V., Máthé E.
Affiliation: Doctoral School of Nutrition and Food Science, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Böszörményi Str. 128, 4032 Debrecen, Hungary
Departament of Pharmaceutical Sciences, Faculty of Pharmacy, „Vasile Goldiș” Western University of Arad, Liviu Rebreanu, no. 86, Arad, Romania
SC PlantExtrakt SRL, 407059-Rădaia, Cluj, Romania
Departament of Pharmacognosy, Faculty of Pharmacy, „Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, V. Babeș no. 8, Cluj-Napoca, Romania
Departament of Biology, Faculty of Medicine, „Vasile Goldiș” Western University of Arad, Liviu Rebreanu, Arad, Romania
Doctoral School of Biology, Faculty of Biology, „Alexandru Ioan Cuza” University of Iași, Bvd. Carol I, no. 11, Iași, Romania
National Institute for Economic Research “Costin C. Kiritescu” of the Romanian Academy/ Centre for Mountain Economy (CE-MONT), Petreni, no. 49, Suceava, Romania
Banat University of Agricultural Sciences and Veterinary Medicine „King Michel I of Romania” in Timișoara, Calea Aradului, no. 119, Romania
Abstract: The Hawthorn and Olive are known from ancient time as phytotherapics with beneficial effect on heart and circulatory system, decreasing or regulating the blood pressure. By HPLC analysis were identified polyphenols with proved effect on angiotensin converting enzyme (ACE), the key compound of blood pressure regulation through renin-angiotensin-aldosterone system. The chlorogenic acid, caffeic acid, luteolin, quercitrin and even hyperosid, have the structural elements to block the active center of ACE. Due by the fact that these compounds are in significant quantities, we can conclude that these phyto- and gemmotherapic extracts’s normo- or hypotensive effect is done also by the mechanism of ACE inhibition.
Keywords: hawthorn and olive gemmotherapic extracts, hawthorn phytotherapic extracts, HPLC, ACE
inhibition, renin-angiotensin-aldosterone system.
*Correspondence: Violeta Turcuș, „Vasile Goldiş” Western University of Arad, Faculty of Medicine, L.Rebreanu str. 86, 310414, Arad,
Romania, e-mail: