Health assessment in occupationally exposed population to inorganic lead


Health assessment in occupationally exposed population to inorganic lead

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Title: Health assessment in occupationally exposed population to inorganic lead
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Article_Title: Health assessment in occupationally exposed population to inorganic lead
Authors: Horatiu Moldovan*, Lorand Szasz, Zsuzsanna Szasz
Affiliation: University of Medicine and Pharmacy, Targu Mureş, Romania
Mures County Clinic Hospital, Romania
Abstract: The regular medical control established by law in professional lead exposure provides a number of investigations required for workers. Our study has included 97 subjects, occupationally exposed to inorganic lead. Clinical examination, blood tests and urine tests were made to all 97 subjects. The study shows that most subjects have increased values of lead in blood, beyond the limit tolerable organic. Urinary concentration of delta-aminolevulinic acid – an indicator of biological effects, has increased, which correlates with a high absorption of lead. Also, creatinine is not particularly important in lead intoxication, being normal or near normal in most cases. Analysing haemoglobin we have found that only a low rate of subjects had normal levels of haemoglobin, which entitles haemoglobin determination as a marker useful in assessing long-term exposure to inorganic lead. Regarding the clinical symptoms we have found that many subjects have at least one symptom related to intoxication / high absorption of inorganic lead but most of them having no symptoms, although elevated sanguine lead was recorded.
Keywords: lead, intoxication, occupational, exposure
References: Bardac D, 1999, Copşa Mică – elemente de monografie medicală şi socială, Tribuna Sibiu, 43-44, 57-69
Cezard C, 1992, Toxicologie du plomb chez l’homme, Editions Medicales Internationales, Paris, 41-43, 49-52, 73-113
Cocârlă A., 2008, Medicina ocupatională, Editura medicală univeristară „Iuliu Haţieganu”, Cluj-Napoca, 961-983
Condura SM, La Pagilia G, 1996, Efetti toxici ambientalie profesionali su la neurotransmisione, Scienze del travoro, 10, 29-34
Niculescu T, 2003, Medicina muncii, Editura Medmun, Bucuresti, 131-137
Szasz L , 2008, Vademecum de medicina muncii, University Press, Tg-Mureş, 130-139
Szasz L, 2008, Eficienţa măsurilor profilactice tehnico-organizatorice în condiţii concrete de extragerea plumbului anorganic, Revista de Medicina si Farmacie – sesiunea cadrelor didactice UMF Tg-Mures, 134
Szasz L, 2008, Tratamentul intoxicaţiei cronice cu plumb anorganic cu D-Penicilamină, Revista de Medicina si Farmacie – sesiunea cadrelor didactice UMF Tg-Mures, 106
Toma I., 2008, Medicina muncii, Editura Sitech, Craiova, 163-180
Conroy LM, Lindsay RMM, Sullivan PM, Cali S, Forst L: Lead, Chromium, and Cadmium exposure during abrasive blasting. Arch Environ Health 1996, 51:95-9.
Dioka CE, Orisakwe OE, Adeniyi FAA, Meludu SC: Liver and renal function tests in artisans occupationally exposed to lead in mechanic village in Nnewi, Nigeria. Int J Environ Res Pub Health 2002, 1:21-5.
Menezes G, D’souza HS, Venkatesh T: Chronic lead poisoning in an adult battery worker. Occup Med 2003, 53:476-478.
James MG, Gulson BL: Engine reconditioning workshop: lead contamination and the potential risk for workers: a pilot study. Occup Environ Med 1999, 56:429-431.
Warren MJ, Cooper JB, Wood SP, Shoolingin-Jordan PM: Lead poisoning, haem synthesis and 5-aminolevulinic acid dehydratase. Trends in Biochemical sciences 1998, 23:217-221.
Read_full_article: pdf/20-2010/20-s1-2010/SU20-s1-2010-Moldovan1.pdf
Correspondence: Moldovan Horatiu, Hygiene Department, University of Medicine anf Pharmacy, Targu-Mures, Romania, e-mail: horatiumoldovan@gmail.com

Read full article
Article Title: Health assessment in occupationally exposed population to inorganic lead
Authors: Horatiu Moldovan*, Lorand Szasz, Zsuzsanna Szasz
Affiliation: University of Medicine and Pharmacy, Targu Mureş, Romania
Mures County Clinic Hospital, Romania
Abstract: The regular medical control established by law in professional lead exposure provides a number of investigations required for workers. Our study has included 97 subjects, occupationally exposed to inorganic lead. Clinical examination, blood tests and urine tests were made to all 97 subjects. The study shows that most subjects have increased values of lead in blood, beyond the limit tolerable organic. Urinary concentration of delta-aminolevulinic acid – an indicator of biological effects, has increased, which correlates with a high absorption of lead. Also, creatinine is not particularly important in lead intoxication, being normal or near normal in most cases. Analysing haemoglobin we have found that only a low rate of subjects had normal levels of haemoglobin, which entitles haemoglobin determination as a marker useful in assessing long-term exposure to inorganic lead. Regarding the clinical symptoms we have found that many subjects have at least one symptom related to intoxication / high absorption of inorganic lead but most of them having no symptoms, although elevated sanguine lead was recorded.
Keywords: lead, intoxication, occupational, exposure
References: Bardac D, 1999, Copşa Mică – elemente de monografie medicală şi socială, Tribuna Sibiu, 43-44, 57-69
Cezard C, 1992, Toxicologie du plomb chez l’homme, Editions Medicales Internationales, Paris, 41-43, 49-52, 73-113
Cocârlă A., 2008, Medicina ocupatională, Editura medicală univeristară „Iuliu Haţieganu”, Cluj-Napoca, 961-983
Condura SM, La Pagilia G, 1996, Efetti toxici ambientalie profesionali su la neurotransmisione, Scienze del travoro, 10, 29-34
Niculescu T, 2003, Medicina muncii, Editura Medmun, Bucuresti, 131-137
Szasz L , 2008, Vademecum de medicina muncii, University Press, Tg-Mureş, 130-139
Szasz L, 2008, Eficienţa măsurilor profilactice tehnico-organizatorice în condiţii concrete de extragerea plumbului anorganic, Revista de Medicina si Farmacie – sesiunea cadrelor didactice UMF Tg-Mures, 134
Szasz L, 2008, Tratamentul intoxicaţiei cronice cu plumb anorganic cu D-Penicilamină, Revista de Medicina si Farmacie – sesiunea cadrelor didactice UMF Tg-Mures, 106
Toma I., 2008, Medicina muncii, Editura Sitech, Craiova, 163-180
Conroy LM, Lindsay RMM, Sullivan PM, Cali S, Forst L: Lead, Chromium, and Cadmium exposure during abrasive blasting. Arch Environ Health 1996, 51:95-9.
Dioka CE, Orisakwe OE, Adeniyi FAA, Meludu SC: Liver and renal function tests in artisans occupationally exposed to lead in mechanic village in Nnewi, Nigeria. Int J Environ Res Pub Health 2002, 1:21-5.
Menezes G, D’souza HS, Venkatesh T: Chronic lead poisoning in an adult battery worker. Occup Med 2003, 53:476-478.
James MG, Gulson BL: Engine reconditioning workshop: lead contamination and the potential risk for workers: a pilot study. Occup Environ Med 1999, 56:429-431.
Warren MJ, Cooper JB, Wood SP, Shoolingin-Jordan PM: Lead poisoning, haem synthesis and 5-aminolevulinic acid dehydratase. Trends in Biochemical sciences 1998, 23:217-221.
*Correspondence: Moldovan Horatiu, Hygiene Department, University of Medicine anf Pharmacy, Targu-Mures, Romania, e-mail: horatiumoldovan@gmail.com