Formulation and manufacturing process of some chewable tablets containing carbamazepine – β – cyclodextrin inclusion complex
November 17, 2014
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| Article Title: | Formulation and manufacturing process of some chewable tablets containing carbamazepine – β – cyclodextrin inclusion complex | ||
| Authors: | Abdalrb G.A., Budura E.A., Toderescu C.D., Sârbu I. | ||
| Affiliation: | University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6 Traian Vuia St., 020956, Bucharest, Romania | ||
| Abstract: | Carbamazepine, the most widely used anticonvulsant in the world, has a variable and delayed absorption and a low oral bioavailability due to its poor aqueous solubility. In order to increase its dissolution, we choose to include it in the cavity of beta-cyclodextrin (β-CD), and the solid binary system was prepared in a 1:1 molar ratio by kneading technique. The inclusion complex was used as the active ingredient in a formulation of chewable tablets. The first party of our study presents the preformulation studies on the powder obtained after mixing the active ingredient with the excipients for direct compression (F-MELT® and magnesium stearate). After we established that our material has a good fowability and compressibility, the chewable tablets were prepared using the direct compression method. The final part of the study presents the pharmacotechnical properties of the tablets. | ||
| Keywords: | Carbamazepine, Inclusion complex, beta-cyclodextrin, chewable tablets | ||
| *Correspondence: | Emma Adriana Budura , University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6 Traian Vuia St., 020956, Bucharest, Romania, email: emmacretu@yahoo.com |
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