Histopathological aspects of the acute acalculous cholecystitis experimentally induced by laparoscopy with L-α-phosphatidylcholine

Authors: Bogdan STANCU*1, Viorel MICLĂUŞ2, Aurel ANDERCOU1, Aurel MIRONIUC1

Affiliation: 1 Second Surgical Department, University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj Napoca

2 Histology Department, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Cluj Napoca


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ABSTRACT. Introduction. The experimental study aimed to induce the acute alithiasic cholecystitis in 20 pigs, injecting L-α-Phosphatidylcholine in the gallbladder using laparoscopy. Materials and methods. After the induction the laparoscopic cholecystectomy was performed after 3 and 7 days. Hematoxylin and eosin stain was done from the sections. Results. The histology emphasized the gallbladder’s inflammation, colagenolysis and vascular alteration. The laparoscopic cholecystectomy on the first group had a medium time of 71 minutes and at the second group medium time was 94 minutes. Conclusions. The experimental induction of acute acalculous cholecystitis is possible injecting using laparoscopy in the gallbladder L-α-Phosphatidylcholine, the inflammatory lesions being emphasized.


Keywords: acute cholecystitis, L-α-Phosphatidylcholine, laparoscopic cholecystectomy, inflammation, colagenolysis