HomeArchivesStudia Univ. VG, SSV, vol. 21, iss. 2, 2011Porous pellets a possibility to obtain a modify release for metoprolol salts

Porous pellets a possibility to obtain a modify release for metoprolol salts

March 21, 2013

Porous pellets a possibility to obtain a modify release for metoprolol salts

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Title: Porous pellets a possibility to obtain a modify release for metoprolol salts
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Article_Title: Porous pellets – a possibility to obtain a modify release for metoprolol salts
Authors: Marouj Daas, Dumitru Lupuleasa, Doina Draganescu, Ali Hamze Mourad
Affiliation: University of Medicine and Pharmacy,,Carol Davila” Bucharest, Departament of Pharmeaceutical Technology and Biopharmacy
University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Physics, 6 Traian Vuia, 020956
Abstract: This study have the objective to obtain porous pellets consisting in a mix of HPMC (hidroxypropylmethylcellulose) and xanthan gum or alginates salts or carrageens salts, and calcium salts soluble in water as gelling agent. This pellets after the removal of the calcium ions via extraction with water was evaluated by loading techniques to incorporate metoprolol salts by two techniques: fluid bed and immersing in a drug solutions. The pellets obtained by extrusion and spheronisation was characterized from residual content in calcium ions, friability and drug loading.
The pellets obtained can be used as carriers from metoprolol salts (succinates and tartrate).
The drug loading studies have shown that immersing the pellets in a drug solution are able to deposit metoprolol salts inside. Using fluidized bed coating no drug was found inside the porous pellets.
Keywords: alginates salts, carrageens salts, and calclium salts soluble in water gelling agent, extrusion, hidroxypropylmethylcellulose, metoprolol salts (succinates and tartrate), spheronisation, xanthan gum.
References: 1. Ahmad Bani-jaber, Mutasin Al-Ghazani,,Sustained Release Characteristics of Tablets Prepared with
Mixed Matrix of sodium carrageens and chitosan” Drug Development and Industrial Pharmacy, vol
30, nr 2, pp 143-150, 2004
3. Crina-Maria Monciu,,Analiza chimică în controlul medicamentelor”, Ed. Medicală, Bucureşti, 2005
4. M. C. Gohel, A. F. Amin, K. V. Patel and M. K. Panchal,,Studies in release behavior of diltiazem
HCl form matrix tablets containing hydroypropyl methyl cellulose and xanthan gum”, Boll.Chim.
Farmac., 141: 21-28 (2002)
5. T. Gold, N. Shterman, Metoprolol succinate extended release tablets and methods for their
preparation, European patent EP18452534, June, 2007
6. Irina Prasacu, Constantin Mircioiu, Roxana Sandulovici, Florin Enache,,Release of matoprolol
from solid dosage forms. Choice and validation of theoretical model” Farmacia 1 pp 89 (2000)
Porous pellets – a possibility to obtain a modify release for metoprolol salts 338 Studia Universitatis “Vasile Goldiş”, Seria Ştiinţele Vieţii Vol. 21, issue 2, 2011, pp. 335-338 ©2011 Vasile Goldis University Press (www.studiauniversitatis.ro)
7. I. Kusai, L. Vlase, I. Tomuţă, S. E. Leucuţa,,Kinetic modeling of hydration hydrophilic matrices
with diclofenac sodium on basis of hydroxypropylmethylcellulose and xanthan gum” Farmacia 4, pp 371-380 (2008)
8. E. Mendel,,Controlled release metoprolol oral composition containing heteropolysaccharides and
method for the preparation thereof” US patent 5399362, April, 1995
9. Michael A. Odeniyi, Kolowole T. Jaiiyeobe,,Optimization of ascorbic acid tablet formulation containing hydrophilic polymers” Farmacia2, vol 5, pp 157 (2009).
10. Simona Raicu, Lelia Lazăr,,Release properties of a biodegradable hydrophylic matrix with alginates” Farmacia 7-8, pp 101-105
11. N. J. Sune, P.M.,,A process for the preparation of controlled-release pharmaceutical composition
of metoprolol” PCT patent application WO 20055084636 September. 2005
12. M.V. Shteinhart,,Tablet with controlled release of metoprolol” Ukraina patent UA135IU Feb, 2006
12. Syed Nissar Hussain Shah, Sajid Asghar, Muhammad Akram Choudhry, Muhammad Sajid Hamid Akash,
formulation and evaluation of natural gum based sustained release matrix tablets of flurbiprofen
using response surface methodology” D.D.I.Ph. 35 (12): 1470 – 1479, 2009
14. J. Sujiaareth, D. L. Munday, P. J.Cox and K. A. Khan,,Relationship between swelling, erosion and
drug release from hydrophilic natural gum minimatrix formulation, Eur. J. Pharm. Sci 6:207-217
(1998)
15. M. M. Talukdar, A. Michel, P. Rombaut and Kinget,,Comparative study on xanthan gum and
hydroxypropylmethyl celluloses matrices for controlled-release drug delivery” Int. J. Pharm.
129, 233-241 (1998)
16. *** European Pharmacopeia, ed. 5, vol 2
17. *** US patent 4879362/2008
18. *** US patent 7838032/2010
Read_full_article: pdf/21-2011/21-2-2011/SU21-2-2011Daas.pdf
Correspondence:

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Article Title: Porous pellets – a possibility to obtain a modify release for metoprolol salts
Authors: Marouj Daas, Dumitru Lupuleasa, Doina Draganescu, Ali Hamze Mourad
Affiliation: University of Medicine and Pharmacy,,Carol Davila” Bucharest, Departament of Pharmeaceutical Technology and Biopharmacy
University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Physics, 6 Traian Vuia, 020956
Abstract: This study have the objective to obtain porous pellets consisting in a mix of HPMC (hidroxypropylmethylcellulose) and xanthan gum or alginates salts or carrageens salts, and calcium salts soluble in water as gelling agent. This pellets after the removal of the calcium ions via extraction with water was evaluated by loading techniques to incorporate metoprolol salts by two techniques: fluid bed and immersing in a drug solutions. The pellets obtained by extrusion and spheronisation was characterized from residual content in calcium ions, friability and drug loading.
The pellets obtained can be used as carriers from metoprolol salts (succinates and tartrate).
The drug loading studies have shown that immersing the pellets in a drug solution are able to deposit metoprolol salts inside. Using fluidized bed coating no drug was found inside the porous pellets.
Keywords: alginates salts, carrageens salts, and calclium salts soluble in water gelling agent, extrusion, hidroxypropylmethylcellulose, metoprolol salts (succinates and tartrate), spheronisation, xanthan gum.
References: 1. Ahmad Bani-jaber, Mutasin Al-Ghazani,,Sustained Release Characteristics of Tablets Prepared with
Mixed Matrix of sodium carrageens and chitosan” Drug Development and Industrial Pharmacy, vol
30, nr 2, pp 143-150, 2004
3. Crina-Maria Monciu,,Analiza chimică în controlul medicamentelor”, Ed. Medicală, Bucureşti, 2005
4. M. C. Gohel, A. F. Amin, K. V. Patel and M. K. Panchal,,Studies in release behavior of diltiazem
HCl form matrix tablets containing hydroypropyl methyl cellulose and xanthan gum”, Boll.Chim.
Farmac., 141: 21-28 (2002)
5. T. Gold, N. Shterman, Metoprolol succinate extended release tablets and methods for their
preparation, European patent EP18452534, June, 2007
6. Irina Prasacu, Constantin Mircioiu, Roxana Sandulovici, Florin Enache,,Release of matoprolol
from solid dosage forms. Choice and validation of theoretical model” Farmacia 1 pp 89 (2000)
Porous pellets – a possibility to obtain a modify release for metoprolol salts 338 Studia Universitatis “Vasile Goldiş”, Seria Ştiinţele Vieţii Vol. 21, issue 2, 2011, pp. 335-338 ©2011 Vasile Goldis University Press (www.studiauniversitatis.ro)
7. I. Kusai, L. Vlase, I. Tomuţă, S. E. Leucuţa,,Kinetic modeling of hydration hydrophilic matrices
with diclofenac sodium on basis of hydroxypropylmethylcellulose and xanthan gum” Farmacia 4, pp 371-380 (2008)
8. E. Mendel,,Controlled release metoprolol oral composition containing heteropolysaccharides and
method for the preparation thereof” US patent 5399362, April, 1995
9. Michael A. Odeniyi, Kolowole T. Jaiiyeobe,,Optimization of ascorbic acid tablet formulation containing hydrophilic polymers” Farmacia2, vol 5, pp 157 (2009).
10. Simona Raicu, Lelia Lazăr,,Release properties of a biodegradable hydrophylic matrix with alginates” Farmacia 7-8, pp 101-105
11. N. J. Sune, P.M.,,A process for the preparation of controlled-release pharmaceutical composition
of metoprolol” PCT patent application WO 20055084636 September. 2005
12. M.V. Shteinhart,,Tablet with controlled release of metoprolol” Ukraina patent UA135IU Feb, 2006
12. Syed Nissar Hussain Shah, Sajid Asghar, Muhammad Akram Choudhry, Muhammad Sajid Hamid Akash,
formulation and evaluation of natural gum based sustained release matrix tablets of flurbiprofen
using response surface methodology” D.D.I.Ph. 35 (12): 1470 – 1479, 2009
14. J. Sujiaareth, D. L. Munday, P. J.Cox and K. A. Khan,,Relationship between swelling, erosion and
drug release from hydrophilic natural gum minimatrix formulation, Eur. J. Pharm. Sci 6:207-217
(1998)
15. M. M. Talukdar, A. Michel, P. Rombaut and Kinget,,Comparative study on xanthan gum and
hydroxypropylmethyl celluloses matrices for controlled-release drug delivery” Int. J. Pharm.
129, 233-241 (1998)
16. *** European Pharmacopeia, ed. 5, vol 2
17. *** US patent 4879362/2008
18. *** US patent 7838032/2010
*Correspondence:

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