Particular morphological aspects of viral C chronic infection in alcoholic liver diseases

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Article Title:	Particular morphological aspects of viral C chronic infection in alcoholic liver diseases
Authors:	Liana Moș, Corina Zorilă, Coralia Cotoraci, George-Ciprian Pribac, Veronica Grec, Adrian Wiener
Affiliation:	1 Department of Internal Medicine, Faculty of Medicine, Pharmacy and Dental Medicine „Vasile Goldis” Western University of Arad 2 Department of Haematology, Faculty of Medicine, Pharmacy and Dental Medicine „Vasile Goldis” Western University of Arad 3 Department of Cell and Molecular Biology, Faculty of Medicine, Pharmacy and Dental Medicine „Vasile Goldis” Western University of Arad
Abstract:	The aim of the study was to evaluate the histological aspects of chronic infection with hepatitis C virus in heavy alcohol drinkers. We selected 84 heavy alcohol drinkers (intake-over 80g ethanol/day for more than 10 years) with alcoholic liver disease (ALD) from wich 34 patients had chronic hepatits C virus (HCV) infection. Liver biopsy was performed in all patients. In alcoholic liver disease the presence of hepatitis C anti-virus antibodies was significantly correlated with the presence of the histological signs of non-alcoholic moderate active chronic hepatitis. The pattern of hepatic histological lesions is dominated by the histological aspects of viral hepatitis chronic infection rather than the typical aspect of alcoholic liver disease. The steatosis was present in both groups. The score of fibrosis was more severe in patients with markers of hepatitis C virus chronic infection and chronic alcohol intake. The histological signs of the alcoholic liver disease were less exhibited in hepatitis C infected group of patients, even though all patients presented the same severe consumption of alcohol. Hepatic histological pattern of the lesions is dominated rather by the histological aspects of viral hepatitis than by the typical aspect of the alcoholic liver disease. Fibrosis was more severe in hepatitis C positive groups, associated with alcohol intake. Alcohol consuming in hepatitis C chronic infection increase the liver dammage and accelerates the rate of fibrosis with mixed dispossition.
Keywords:	viral C infection, alcoholic liver disease
References:	Cheryl PH, Cherpitel J. Brief screening instruments for alcoholism Alcohol Health & Research World, Vol. 21, No. 4, pp. 348-351, 1997 Ostapowicz G, Katrina J. R. Watson, Stephen A. Locarnini, and Paul V. Desmond Role of Alcohol in the Progression of Liver Disease Caused By Hepatitis C Virus Infection.Hepatology, Iunie, pp. 1730-1735, Vol. 27, No. 6, 1998 Mitchell MC, Herlong HF. Alcohol and nutrition: caloric value, bioenergetics, and relationship to liver damage. Ann Rev Nutr, 6, pp. 457-474, 1986 National Institutes of Health (NIH) consensus development conference panel statement: management of hepatitis C. Hepatology, 26, Suppl 1:2S–10S, 1997 Becker U, Deis A, Sørensen TI, Gronbaek M, Borch- Johnsen K, Muller CF et al. Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. Hepatology, 23, pp. 1025-1029, 1997 Maddrey WC. Alcohol and the liver: an overview. In Hall P, editor. Alcoholic liver disease. London: Edward Arnold, 3-13, 1995 Schiff ER, de Medina M, Kahn RS. New perspectives in the diagnostic of hepatitis C. Semin Liv. Dis.; 19 (Suppl 1), pp. 3-15, 1999 Linda Lowen, Perspectives in general microbiology, Spring 1999 Day CP, James OF. Hepatic steatosis: innocent bystander or guilty party? Hepatology, 27:1463-6, 1998 Lindros K.O.- Alcoholic liver disease- Pathobiological aspects – J. Hepatology, 25 (suppl 1), pp. 7-15, 1995
*Correspondence:	Liana Moș, Department of Internal Medicine, Faculty of Medicine, Pharmacy and Dental Medicine „Vasile Goldis” Western University of Arad, tel/fax: +40-257-212204, email: limmos2001@yahoo.com