Protective effects of Selenium and Zinc on Nickel Chloride induced reproductive toxicity in Wistar Albinos preimplanted rats

 

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Article Title: Protective effects of Selenium and Zinc on Nickel Chloride induced reproductive toxicity in Wistar Albinos preimplanted rats
Authors: Boulila I., Ounassa A.
Affiliation: Faculty of Natural and Life Sciences, Department of Organisms Biology, University of Batna2, Algeria
Research Laboratory of Physio-Toxicology, Pathology, cellular and bimolecular molecular
Abstract: The aim of this study was to investigate that nickel chloride (NiCl2) induced reproductive toxicity in pre- implanted Wistar Rats and examined the possible protective effect of zinc chloride and selenium on plasma concentration of the hormones of 17 b etradiol (E2) and progesterone (prog); on the reproductive organ’s histology and on development. Experimental results showed the subcutaneous (s.c) administration of Nicl2 to Wistar albino Rats induced a decrease in plasma concentration of E2 and prog in addition, disturbance in development parameters and structural damages to the histology of the reproductive organs. Conversely, Se and ZnCl2 dues to the antioxidants property, regulate the secretion of E2 and Prog hormones, prevent alterations in the reproductive organs and in development in preimplanted rates receiving NiCl2.
Keywords: pre-implanted rat; nickel chloride; selenium; zinc chloride; reproductive toxicity
*Correspondence: Ismahene Boulila, Faculty of Natural and Life Sciences, Department of Organisms Biology, University of Batna2,
Algeria, e-mail: ismahenboulila@gmail.com, physiosally@hotmail.fr