TG/DTG/DTA data used to determine the thermal behaviour of pioglitazone

November 17, 2014

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Article Title:	TG/DTG/DTA data used to determine the thermal behaviour of pioglitazone
Authors:	Albu P., Vlase G., Vlase T.
Affiliation:	1 West University of Timisoara, Research Center for Thermal Analysis in Environmental Problems, 16 Pestalozzi St., Timisoara, RO-300115, Romania 2„Vasile Goldis” West University of Arad, Faculty of Medicine, Pharmacy and Dentistry, Department of Pharmacy, 86 L. Rebreanu St., 310414 Arad, Romania
Abstract:	Pioglitazone is a drug from the thiazolidinediones group and it is used in the treatment of type II diabetes mellitus by decreasing insulin resistance. Thermal degradation involves different reactions like pyrolysis, hydrolysis, decarboxylation, isomerization, rearrangement and polymerization of the active substance, hence the importance of studying the thermal behaviour of pharmaceutical compounds. This study was performed using just one heating rate of 10°C•min-1, in air atmosphere. Data collected from TG/DTG/DTA analysis was used to determine the thermal behavior and thermal stability of the pharmaceutical active agent.
Keywords:	Pioglitazone, Thermal behavior, FTIR, Diabetes, TG/DTG/DTA
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*Correspondence:	Paul Albu, Vasile Goldis” West University of Arad, Faculty of Medicine, Pharmacy and Dentistry, Department of Pharmacy, 86 L. Rebreanu St., 310414 Arad, Romania