Investigation of thermally induced interactions between pioglitazone and some excipients by FT-IR and DSC analysis

November 17, 2014

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Article Title:	Investigation of thermally induced interactions between pioglitazone and some excipients by FT-IR and DSC analysis
Authors:	Albu P., Ardelean D., Santa I., Vlase G., Vlase T
Affiliation:	1West University of Timisoara, Research Center for Thermal Analysis in Environmental Problems, 16 Pestalozzi St., Timisoara, RO-300115, Romania 2„Vasile Goldis” West University of Arad, Faculty of Medicine, Pharmacy and Dentistry, Department of Pharmacy,
Abstract:	This aim of this paper is to determine potential thermally induced drug-excipient interactions between pioglitazone, a drug in the thiazolidinediones group and a series of different excipients. The drug is used in the treatment of type II diabetes mellitus by decreasing insulin resistance. The study was performed on the active compound, on the excipients and on the binary mixtures. (1:1, w/w), using two of the most important methods of investigation of compatibility between a pharmaceutical agent and excipients: FT-IR spectroscopy and DSC analysis. Results showed that no interactions occur that alter the molecular structure of the active compound.
Keywords:	Pioglitazone ∙ Excipients ∙ FT-IR ∙ DSC analysis
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*Correspondence:	Paul Albu, Vasile Goldis” West University of Arad, Faculty of Medicine, Pharmacy and Dentistry, Department of Pharmacy, 86 L. Rebreanu St., 310414 Arad, Romania