Evaluation of renin-angiotensin system genes polymorphisms and its corelation with paraoxonase 1 activity in a heterogenous group of hypertensive pacients
November 17, 2014
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| Article Title: | Evaluation of renin-angiotensin system genes polymorphisms and its corelation with paraoxonase 1 activity in a heterogenous group of hypertensive pacients |
| Authors: | Popa C., Pilat L., Ilie D., Popescu C. |
| Affiliation: | Faculty of Medicine, Pharmacy and Dental Medicine, Vasile Goldiș Western University of Arad, Rebreanu Street 86 Arad Laboratory of Molecular Biology, S.C.D.C.B. Arad, Bodrogului 32, Arad Laboratory of Molecular Biology, Institute of Life Sciences, Vasile Goldis Western University of Arad, Liviu Rebreanu 86, Arad. |
| Abstract: | Introduction: The association of polymorphisms of the RAS genes on the incidence of hypertension its still under debate and more over it seems to be population-dependent. Aim: We studied correlations between the angiotensinogen T174M and M235T and angiotensin II receptor 1 (AT1R) A1166C and angiotensin II receptor 2 (AT2R2) C3123A gene polymorphisms and human paraoxonase 1 (PON 1) activity in hypertensive#mce_temp_url# group of patients. Method: 100 patients of a medium and old age have been investigated clinically and subjected to a stress questionnaire. Familial inquiry up to 3 rd generation has been recorded. The RFLP-PCR was used to detect the target mutations in RAS genes. Paraoxonase activity was recorded from plasma serum samples. Conclusions: Our results showed strong association of RAS polymorphism with PON1 in a specific study group. We stress out the importance of genetic analysis for essential hypertension and that the possibility of inter-population differences in genetic factors should be kept in mind. |
| Keywords: | hypertension, RAS polymorphism, human paraoxonase , cardiovascular risk |
| References: | |
| *Correspondence: | Cristina Popescu, Laboratory of Molecular Biology, Institute of Life Sciences, Vasile Goldis Western University of Arad, Liviu Rebreanu 86, Arad. |
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