Adherence to a colorectal cancer screening using the faecal immunochemical test

Adherence to a colorectal cancer screening using the faecal immunochemical test

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Title: Adherence to a colorectal cancer screening using the faecal immunochemical test
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Article_Title: Adherence to a colorectal cancer screening using the faecal immunochemical test
Authors: Bogdan Miuţescu, Ioan Sporea, Alina Popescu, Simona Bota, Dana Iovănescu, Eftimie Miuţescu
Affiliation: Department of Gastroenterology, “Vasile Goldiş” West University Arad
Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy “Victor Babes” Timişoara
Abstract: The objective of our study was to estimate the adherence to a colorectal cancer (CCR) screening programme, using the faecal immunochemical test (FIT). Materials and methods: In this study we analysed the adherence to a CCR screening programme in an average risk population aged between 50 and 74 years. A qualitative FIT was used and colonoscopy was recommended for patients with positive results. Results. In our study 2967 subjects were invited to participate in the CRC screening programme. From all invited persons, 1389 (46.8%) performed the FIT. Compliance to FIT was significantly higher among women as compared with men: 49.1% vs. 43.9%, p=0.005. Also, the compliance to FIT was significantly higher in subjects from urban area as compared with those from rural area: 48.7% vs. 41.9%, p=0.0009. The adherence to FIT was higher in age group 70-74 years as compared with the others age groups. Colonoscopy was performed in 57/87 of positive FIT subjects (65.5%). Conclusions. Adherence rate for FIT was 46.8%. Participants with positive test results had a compliance rate for follow-up colonoscopy of 65.5%.
Keywords: screening, colorectal cancer, faecal immunochemical test, adherence, compliance
References: Betes M, Munoz-Navas MA, Duque JM et al: Use of colonoscopy as a primary screening test for colorectal cancer in average risk people. Am J Gastroenterol; 98: 2648–2654, 2003.
Crotta S, Castiglione G, Grazzini G, Valle F, Mosconi S & Rosset R. Feasibility study of colorectal cancer screening by immunochemical faecal occult blood testing: results in a northern Italian community, Eur.J.Gastroenterol.Hepatol., vol. 16, no. 1, pp. 33-37,2004.
Denberg TD, Melhado TV, Coombes JM, Beaty BL, Berman K, Byers TE, Marcus AC, Steiner JF & Ahnen DJ: Predictors of nonadherence to screening colonoscopy, J.Gen.Intern.Med., vol. 20, no. 11, pp. 989-995,2005.
Everett T, Bryant A, Griffin MF, Martin-Hirsch PP, Forbes CA, Jepson RG, Interventions targeted at women to encourage the uptake of cervical screening, Cochrane Database Syst Rev. May 11;(5), 2011.
Federici A, Giorgi RP, Bartolozzi F, Farchi S, Borgia P & Guastcchi G, The role of GPs in increasing compliance to colorectal cancer screening: a randomised controlled trial (Italy), Cancer Causes Control, vol. 17, no. 1, pp. 45-52, 2006.
Fenocchi E, Martinez L, Tolve J, Montano D, Rondan M, Parra-Blanco A & Eishi Y, Screening for colorectal cancer in Uruguay with an immunochemical faecal occult blood test, Eur.J.Cancer Prev., vol. 15, no. 5, pp. 384-390, 2006.
Fournel I, Cottet V, Binquet C, Jooste V, Faivre J, Bouvier AM, Bonithon-Kopp C, Rural-urban inequalities in detection rates of colorectal tumours in the population, Dig Liver Dis, Feb;44(2):172-7, 2012.
Frederiksen B L, Jørgensen T, Brasso K, Holten I, and Osler M. Socioeconomic position and participation in colorectal cancer screening. Br J Cancer. November 9; 103(10): 1496–1501. 2010.
Grazzini G, Castiglione G, Ciabattoni C, Franceschini F, Giorgi D, Gozzi S, Mantellini P, Lopane P, Perco M, RubecaT, Salvadori P, Visioli CB & Zappa M, Colorectal cancer screening programme by faecal occult blood test in Tuscany: first round results, Eur.J.Cancer Prev., vol. 13, no. 1, pp. 19-26, 2004.
Haiyun Yang, Zhizheng Ge, Jun Dai,Xiaobo Li, Yunjie Gao: Effectiveness of the Immunofecal Occult Blood Test for Colorectal Cancer Screening in a Large PopulationDig Dis Sci, 56:203–207,2011.
Hol L, van Leerdam ME, van BM, van Vuuren AJ, van DH, Reijerink JC, van der Togt AC, Habbema JD & Kuipers EJ, Screening for colorectal cancer: randomised trial comparing guaiac-based and immunochemical faecal occult blood testing and flexible sigmoidoscopy, Gut, vol. 59, no. 1, pp. 62-68, 2010.
Kahl CJ, Imperiale TF, Juliar BE, Rex DK. Effect of screening colonoscopy on colorectal cancer incidence and mortality, Clin. Gastroenterol. Hepatol., vol.7, 7, 770-775, 2009.
Levi Z, Birkenfeld S, Vilkin A et al.: A higher detection rate for colorectal cancer and advanced adenomatous polyp for screening with immunochemical fecal occult blood test than guaiac fecal occult blood test, despite lower compliance rate. A prospective, controlled, feasibility study, Int. J. Cancer: 128, 2415–2424, 2011.
Morikawa T, Kato J, Yamaji Y, Wada R, Mitsushima T, Shiratori Y: A comparison of the immunochemical fecal occult blood test and total colonoscopy in the asymptomatic population. Gastroenterology; 129:422–428, 2005.
Popescu A, Sporea I: Screeningul cancerului de colon intre ideal si posibilitati; 9-20; 45-103 Editura Mirton, 2009.
Quirke P, Risio M, Lambert R, von Karsa L, Vieth M. European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition-Quality assurance in pathology in colorectal cancer screening and diagnosis, Endoscopy, Sep; 44 Suppl 3:SE116-30, 2012.
Sabesan S, Piliouras P, Disparity in cancer survival between urban and rural patients–how can clinicians help reduce it? Rural Remote Health. Jul-Sep;9(3):1146. Epub 2009 Jul 17, 2009.
Saito H, Colorectal cancer screening using immunochemical faecal occult blood testing in Japan, J.Med.Screen., vol. 13 Suppl 1, p. S6-S7, 2006.
Vijan S, Hwang EW, Hofer TP, Hayward RA. Which colon cancer screening test? a comparison of costs, effectiveness, and compliance. Am J Med.; 111 (8):593–601, 2001.
van Rossum LGM, van Rijn AF, Laheij RJF, et al: Cut-off value determines the performance of a semi-quantitative immunochemical faecal occult blood test in a colorectal cancer screening programme. British Journal of Cancer; 101: 1274 – 1281, 2009.
Wallace PM, Suzuki R. Regional, racial, and gender differences in colorectal cancer screening in middle-aged African-Americans and Whites. J Cancer Educ. Dec;27(4):703-8, 2012.
Zorzi M, Falcini F, Fedato C, Grazzini G, de’ Bianchi PS, Senore C, Vettorazzi M, Visioli C, Zappa M. Screening for colorectal cancer in Italy: 2006 survey. Epidemiol Prev. Mar-Apr;32(2 Suppl 1):55-68, 2008 .
Read_full_article: pdf/23-2013/23-2013/SU23-2-14Miutescu.pdf
Correspondence: Bogdan Miuţescu, Department of Gastroenterology, Clinical County Emergency Hospital Arad, No. 2-4 Andreny Karoly St., 310037, Arad, Romania, Tel. +40357407200, Fax. +40357407211, email: bmiutescu@yahoo.com

Read full article
Article Title: Adherence to a colorectal cancer screening using the faecal immunochemical test
Authors: Bogdan Miuţescu, Ioan Sporea, Alina Popescu, Simona Bota, Dana Iovănescu, Eftimie Miuţescu
Affiliation: Department of Gastroenterology, “Vasile Goldiş” West University Arad
Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy “Victor Babes” Timişoara
Abstract: The objective of our study was to estimate the adherence to a colorectal cancer (CCR) screening programme, using the faecal immunochemical test (FIT). Materials and methods: In this study we analysed the adherence to a CCR screening programme in an average risk population aged between 50 and 74 years. A qualitative FIT was used and colonoscopy was recommended for patients with positive results. Results. In our study 2967 subjects were invited to participate in the CRC screening programme. From all invited persons, 1389 (46.8%) performed the FIT. Compliance to FIT was significantly higher among women as compared with men: 49.1% vs. 43.9%, p=0.005. Also, the compliance to FIT was significantly higher in subjects from urban area as compared with those from rural area: 48.7% vs. 41.9%, p=0.0009. The adherence to FIT was higher in age group 70-74 years as compared with the others age groups. Colonoscopy was performed in 57/87 of positive FIT subjects (65.5%). Conclusions. Adherence rate for FIT was 46.8%. Participants with positive test results had a compliance rate for follow-up colonoscopy of 65.5%.
Keywords: screening, colorectal cancer, faecal immunochemical test, adherence, compliance
References: Betes M, Munoz-Navas MA, Duque JM et al: Use of colonoscopy as a primary screening test for colorectal cancer in average risk people. Am J Gastroenterol; 98: 2648–2654, 2003.
Crotta S, Castiglione G, Grazzini G, Valle F, Mosconi S & Rosset R. Feasibility study of colorectal cancer screening by immunochemical faecal occult blood testing: results in a northern Italian community, Eur.J.Gastroenterol.Hepatol., vol. 16, no. 1, pp. 33-37,2004.
Denberg TD, Melhado TV, Coombes JM, Beaty BL, Berman K, Byers TE, Marcus AC, Steiner JF & Ahnen DJ: Predictors of nonadherence to screening colonoscopy, J.Gen.Intern.Med., vol. 20, no. 11, pp. 989-995,2005.
Everett T, Bryant A, Griffin MF, Martin-Hirsch PP, Forbes CA, Jepson RG, Interventions targeted at women to encourage the uptake of cervical screening, Cochrane Database Syst Rev. May 11;(5), 2011.
Federici A, Giorgi RP, Bartolozzi F, Farchi S, Borgia P & Guastcchi G, The role of GPs in increasing compliance to colorectal cancer screening: a randomised controlled trial (Italy), Cancer Causes Control, vol. 17, no. 1, pp. 45-52, 2006.
Fenocchi E, Martinez L, Tolve J, Montano D, Rondan M, Parra-Blanco A & Eishi Y, Screening for colorectal cancer in Uruguay with an immunochemical faecal occult blood test, Eur.J.Cancer Prev., vol. 15, no. 5, pp. 384-390, 2006.
Fournel I, Cottet V, Binquet C, Jooste V, Faivre J, Bouvier AM, Bonithon-Kopp C, Rural-urban inequalities in detection rates of colorectal tumours in the population, Dig Liver Dis, Feb;44(2):172-7, 2012.
Frederiksen B L, Jørgensen T, Brasso K, Holten I, and Osler M. Socioeconomic position and participation in colorectal cancer screening. Br J Cancer. November 9; 103(10): 1496–1501. 2010.
Grazzini G, Castiglione G, Ciabattoni C, Franceschini F, Giorgi D, Gozzi S, Mantellini P, Lopane P, Perco M, RubecaT, Salvadori P, Visioli CB & Zappa M, Colorectal cancer screening programme by faecal occult blood test in Tuscany: first round results, Eur.J.Cancer Prev., vol. 13, no. 1, pp. 19-26, 2004.
Haiyun Yang, Zhizheng Ge, Jun Dai,Xiaobo Li, Yunjie Gao: Effectiveness of the Immunofecal Occult Blood Test for Colorectal Cancer Screening in a Large PopulationDig Dis Sci, 56:203–207,2011.
Hol L, van Leerdam ME, van BM, van Vuuren AJ, van DH, Reijerink JC, van der Togt AC, Habbema JD & Kuipers EJ, Screening for colorectal cancer: randomised trial comparing guaiac-based and immunochemical faecal occult blood testing and flexible sigmoidoscopy, Gut, vol. 59, no. 1, pp. 62-68, 2010.
Kahl CJ, Imperiale TF, Juliar BE, Rex DK. Effect of screening colonoscopy on colorectal cancer incidence and mortality, Clin. Gastroenterol. Hepatol., vol.7, 7, 770-775, 2009.
Levi Z, Birkenfeld S, Vilkin A et al.: A higher detection rate for colorectal cancer and advanced adenomatous polyp for screening with immunochemical fecal occult blood test than guaiac fecal occult blood test, despite lower compliance rate. A prospective, controlled, feasibility study, Int. J. Cancer: 128, 2415–2424, 2011.
Morikawa T, Kato J, Yamaji Y, Wada R, Mitsushima T, Shiratori Y: A comparison of the immunochemical fecal occult blood test and total colonoscopy in the asymptomatic population. Gastroenterology; 129:422–428, 2005.
Popescu A, Sporea I: Screeningul cancerului de colon intre ideal si posibilitati; 9-20; 45-103 Editura Mirton, 2009.
Quirke P, Risio M, Lambert R, von Karsa L, Vieth M. European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition-Quality assurance in pathology in colorectal cancer screening and diagnosis, Endoscopy, Sep; 44 Suppl 3:SE116-30, 2012.
Sabesan S, Piliouras P, Disparity in cancer survival between urban and rural patients–how can clinicians help reduce it? Rural Remote Health. Jul-Sep;9(3):1146. Epub 2009 Jul 17, 2009.
Saito H, Colorectal cancer screening using immunochemical faecal occult blood testing in Japan, J.Med.Screen., vol. 13 Suppl 1, p. S6-S7, 2006.
Vijan S, Hwang EW, Hofer TP, Hayward RA. Which colon cancer screening test? a comparison of costs, effectiveness, and compliance. Am J Med.; 111 (8):593–601, 2001.
van Rossum LGM, van Rijn AF, Laheij RJF, et al: Cut-off value determines the performance of a semi-quantitative immunochemical faecal occult blood test in a colorectal cancer screening programme. British Journal of Cancer; 101: 1274 – 1281, 2009.
Wallace PM, Suzuki R. Regional, racial, and gender differences in colorectal cancer screening in middle-aged African-Americans and Whites. J Cancer Educ. Dec;27(4):703-8, 2012.
Zorzi M, Falcini F, Fedato C, Grazzini G, de’ Bianchi PS, Senore C, Vettorazzi M, Visioli C, Zappa M. Screening for colorectal cancer in Italy: 2006 survey. Epidemiol Prev. Mar-Apr;32(2 Suppl 1):55-68, 2008 .
*Correspondence: Bogdan Miuţescu, Department of Gastroenterology, Clinical County Emergency Hospital Arad, No. 2-4 Andreny Karoly St., 310037, Arad, Romania, Tel. +40357407200, Fax. +40357407211, email: bmiutescu@yahoo.com