Relationship between glycosylated hemoglobin and lipid metabolism in patients with type 2 diabetes

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Article Title:	Relationship between glycosylated hemoglobin and lipid metabolism in patients with type 2 diabetes
Authors:	Gligor Ramona, Crisnic Ioan, Talpes Simona, Pilat Luminita, Ghinga Simona, Maris Lavinia
Affiliation:	1 Biochemistry Department, Faculty of Medicine, Pharmacy and Dental Medicine. “Vasile Goldis” Western University Arad, Romania 2 S.C. Laborator Analize SRL Arad
Abstract:	Diabetic patients with accompanied dislipidemia are soft targets of cardiovascular deaths. An early intervention to normalize plasmatic lipids has been shown to reduce cardiovascular complication and mortality at type 2 diabetic patients. Glicated hemoglobin (HbA1c) is a used marker for long term glycemic control. His investigation is an attempt to evaluate the diagnostic value of HbA1c in predicting ddiabetic dislipidemia. Venous blood was collected from 112 type 2 diabetic patients age 35 – 75 years, 62 males and 50 females. The sera were analysed for HbA1c, basal blood glucose, total cholesterol, tryglicerides, high density lipoprotein cholesterol (HDL cholesterol) and low density lipoprotein cholesterol (LDL cholesterol). The levels of HbA1c did not differ significantly between males and females. HbA1c showed direct and significant correlation with cholesterol, triglicerides and LDL cholesterol, and revers correlation with HDL cholesterol. Female diabetic patients had significantly higher levels of serum cholesterol and HDL cholesterol compared to males. They were no significant differences in triglicerides in LDL between the two genders. There was a significant increase in triglicerides in the patients of both genders with impaired glicemic control. Both males and females patients with worse glicemic control (HbA1c > 9%) had significantly high cholesterol and LDL levels. Serum HDL showed a significant and inverse relationship with uncontrolled hiperglicemia in females but not in males. These findings clearly suggest that HbA1c can provide valuable suplimentary information about the extent of circulating lipids besides in its primary role in monitoring long term glycemic control. Further studies are warranted to reinforce the potential of HbA1c as a biomarker for screening of high risk diabetic patients.
Keywords:	type 2 diabetes, dyslipidemia, glycemic control, HbA1c
References:	1. Avogaro A, Jiorda C, Maggini M, Mannucci E, Raschetty R, Lobardo F et all (207) incidence of coronary heart disease in type 2 diabetic woman and man : Impact of microvascular complications, treatement and geogrfic location. Diabetes Care (30-5) : 1241 – 1247 2. Bellomo A, Manchinella M, Troisi G, Ettorre E, Marigliano V (2007) diabetes and metabolic syndrome (MS. Arch Gerontol Geriatl 44 : 61-61) 3. Berry C. Tardif JC, Bourassa MG. Coronary heart disease in patient with diabetes: part 1: recent advances in prevention and noninvasive management . J Am Coll Cardiol 49 : 631 – 642 4. Chan WB, Thong PC, Chow CC, Sow WY, Ng MC, Ma RC, Osaky R, Cockram CS, Chan JC (205) Trigliceride Predict cardiovascular mortality and its relationship with glycemia and obesity in Chinese type 2 patients. Diabetes Metab Res Rev 21 : 183 – 188 5. Cucuianu M. Insulin Resistance metabolic syndrome and Thromboaterosclerosis. Bull. Mol . Med. Nos 7-8 Spring 6. Eshaghian S, Horwick TB, Fonarov GC (2006) . An unexpected inverse relationship between HbA1c levels and mortality in patients with diabetes and advances systolic heart failure. Am Heart 151 -191 7. Esteghamati A, Abbasi M, Nagjavani M, Yousefizadeh A, Basa AP, Afhar H (2006) prevalence of diabetes and other cardiovascular risk factor in an irranian population with acute coronary syndrome. Cardiovas Diabetol 5 : 15 8. Gotto AM Jr (2007) Cardiologist-s role in improving glucose control and global cardiovascular risk in patients with type 2 diabetes mellitus. Am J Cardiol 99 : 35 9. Haseb Ahmad Khan : Clinical significance of HbA1c as a marker of circulating lipids in male and female type 2 diabetic patients. Acta Diabetol (2007) 44 : 193 : 200 10. Howard B, Cowan L, Go O, Welty T, Robinson D, Lee E (1998) adverse effect of diabetes and multiple cardiovascular desease risk factors in woman : the Strong Hearth Study Diabetes Care 21:125 – 1258 – 1265 11. Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M (1998) mortality from coronary heart disease in subject with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Angle J. Med. 339: 229-234 12. Pamela C. Champe, R A . Harvey. Dende R. Ferrier : Biochimie editia a IV – a, 337 – 399 13. Iones PH (206) Clinical Significance of recent lipid trial on reducing risk in patients with type 2 diabetes mellitus. Am J Cardiol : 99:133-140 14. Ko GT, Chan JC, Woo I, Lau E, Eung WT, Chow CC, Lee KJ, Sow WY, Chan WB, Cockram CS (1998) Glycated Hemoglobin and cardiovascular risk factors in Chinese Subjects with normal glucose tolerance . Diabet Med 15 – 573 – 587 15. Mohamad M, Arshad F, Noorr MIM, Aly R (1997) prevalence of dislipidemia in noninsuline dependent diabetic patients attending armed forces clinics in Coala Lum Pur. Asia Pacific J Clean Nutr 6 : 203 – 206 16. Ko GT, Chan JC, Woo I, Lau E, Eung WT, Chow CC, Lee KJ, Sow WY, Chan WB, Cockram CS (1998) Glycated Hemoglobin and cardiovascular risk factors in Chinese Subjects with normal glucose tolerance . Diabet Med 15 – 573 – 587 17. Nistor T, Cucuianu M, Hancu N, Orbai P : Serum Cholinesteraza Activity 18. Nakamura K, Yamagishi SI, Adaki H, Kurita – Nakamura Y, Matsui T, Yoshida T, Sato A, Imaizumi T (2007), elevation of Soluble Form Of Receptor For Advanced glication and products s Rage in diabetic subjects with coronary artery disease. Diabetes Metab. Res Rev. 23 (5) 368 + 371 19. The Diabetes Prevention Program Research group (205) Lipid, Lipoprotein C, C reactive Protein and hemostatic factor et baseline in the diabetes prevention program . Diabtes Care 28 : 2472 – 2479 20. Wexler DJ Grant RW, Meigs JB, Natham DM, Cagliero M (205) Sex disparities in treatement of cardial risk factors in Patients with type 2 diabetes care 28 : 514 – 520 21. Walder C, Knopp R, Wahl P, Beach K, Strandness E (1984) Sex differences in the effect of diabetes mellitus on lipoprotein triglicerides and cholesterol concentration. Engl J Med 311 : 953 – 959
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