Patterns of the vascular endothelial growth factor immune-histochemical expression in lung carcinomas

Patterns of the vascular endothelial growth factor immune-histochemical expression in lung carcinomas

This is an automatically generated default intro template – please do not edit.


General information


Title: Patterns of the vascular endothelial growth factor immune-histochemical expression in lung carcinomas
Meta keywords:
Meta description:

Images information


Images path absolute: /home/studia/public_html/v15/images/stories/com_form2content/p3/f151
Images path relative: com_form2content/p3/f151
Thumbs path absolute:
Thumbs path relative:

Fields information


Article_Title: Patterns of the vascular endothelial growth factor immune-histochemical expression in lung carcinomas
Authors: Amalia Birau, Raluca Amalia Ceausu, Anca Maria Cimpean, Pusa Gaje, Gheorghe Ciobanu, Teodora Olariu, Marius Raica
Affiliation: „Vasile Goldis” Western University of Arad, Department of Intensive Care
„Vasile Goldis” Western University of Arad, Department of Radiology
”Victor Babes” University of Medicine and Pharmacy, Department of Histology, Timisoara, Romania
Abstract: Vascular endothelial growth factor (VEGF) has been demonstrated as the main angiogenic molecule in vitro and in vivo. The involvement of VEGF in the prognosis and progression of different types of tumors has been demonstrated by many publications. In the present study we have investigated the patterns of the immunohistochemical expression of VEGF in lung carcinoma. We have investigated 42 biopsies from patients admitted with different histological types of lung carcinoma. The aim of this investigation was to describe the incidence and models of distribution of the positive reaction for VEGF in lung carcinoma. The reaction for VEGF has been evaluated using a scale from 0 (negative) to 3 (strong positive), based on the percentage of positive cells. We found a strong expression for VEGF in cases with squamous cells carcinoma, adenocarcinoma and hepatoid carcinoma, and negative reaction in small cell and large cell carcinomas. Our data suggest that the incidence and intensity of VEGF expression in lung carcinoma can be a good indicator of antiangiogenic therapy based on humanized monoclonal antibody against VEGF.
Keywords: lung carcinoma, vascular endothelial growth factor (VEGF), angiogenesis
References: Aikawa H, Takahashi H, Fujimura S, Sato M, Endo C, Sakurada A, Kondo T, Tanita T, Matsumura Y, Ono S, Saito Y, Sagawa M. Immunohistochemical study on tumor angiogenic factors in non-small cell lung cancer, Anticancer Res., 1999; 19(5B):4305-9.
Bremnes R M, Carlos Camps, Rafael Sirera, Angiogenesis in non-small cell lung cancer: The prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood, Lung Cancer, 2006, 51 (2): 143-158.
Chaudhry IH, O’Donovan DG, Brenchley PE, Reid H, Roberts IS, Vascular endothelial growth factor expression correlates with tumour grade and vascularity in gliomas, Histopathology, 2001, 39(4): 409-415.
Folkman J, Merler E, Abernathy C, Williams G – Isolation of a tumor factor responsible for angiogenesis, J Exp Med. 1971, 133:275-288.
Fontanini G, Boldrini L, Vignati S, Chinè S, Basolo F, Silvestri V, Lucchi M, Mussi A, Angeletti CA, Bevilacqua G Bcl2 and p53 regulate vascular endothelial growth factor (VEGF)-mediated angiogenesis in non-small cell lung carcinoma, Eur J Cancer. 1998, 34(5):718-723.
Inda AM, Andrini LB, García MN, García AL, Fernández Blanco A, Furnus CC, Galletti SM, Prat GD, Errecalde AL, Evaluation of angiogenesis with the expression of VEGF and CD34 in human non-small cell lung cancer, J Exp Clin Cancer Res., 2007,
26(3):375-378.
S. Ishigami, S Arii, M Furutani, M Niwano, T Harada, M Mizumoto, A Mori, H Onodera and M Imamura, Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer, Britsh Jourmal of Cancer, 1998, 78(10): 1379-1384.
Jarzynka MJ, Guo P, Bar-Joseph I, Hu B, Cheng SY., Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis, Int J Oncol., 2006, 28(2):337-344.
Li X, Zhang Q, Lu B, Qiu X, Luo Y, Zhang W, Xu S, Expression of DLL4 and VEGF in Lung Adenocarcinoma and their Relationship with Angiogenesis in Tumor, Zhongguo Fei Ai Za Zhi. 2009, 12(2):117-121.
Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z., Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 1999 Jan;13(1):9-22.
Ribatti D., The contribution of Harold F. Dvorak to the study of tumor angiogenesis and stroma generation mechanisms, Endothelium, 2007, 14(3):131-135.
Spira A, Ettinger DS. Multidisciplinary management of lung cancer. N Engl J Med 2004;350:379-392.
Toshiro Niki, Sanae Iba, Masahide Tokunou, Tesshi Yamada, Yoshihiro Matsunoand, Setsuo Hirohashi, Expression of Vascular Endothelial Growth Factors A, B, C, and D and Their Relationships to Lymph Node Status in Lung Adenocarcinoma, Clin Cancer Res, 2000, 6:2431-2439.
Tanno S, Ohsaki Y, Nakanishi K, Toyoshima E, Kikuchi K, Human small cell lung cancer cells express functional VEGF receptors, VEGFR-2 and VEGFR-3., Lung Cancer. 2004; 46(1):11-19.
Takahama M, Tsutsumi M, Tsujiuchi T, Kido A, Okajima E, Nezu K, Tojo T, Kushibe K,Kitamura S, Konishi Y. Frequent expression of the vascular endothelial growth factor in human non-small-cell lung cancers. Jpn J Clin Oncol. 1998; 28(3):176-181.
Yuan A, Yu CJ, Chen WJ, Lin FY, Kuo SH, Luh KT, Yang PC, Correlation of total VEGFmRNA and protein expression with histologic type, tumor angiogenesis, patient survival and timing of relapse in non-small-cell lung cancer., Int J Cancer., 2000;
89(6):475-483.
Read_full_article: pdf/22-2012/22-1-2012/SU22-1-2012-Birau2.pdf
Correspondence: Amalia Birau, MD, PhD student Department of Intensive Care, „Vasile Goldis” Western University of Arad, no.1 Feleacului St., Arad, Romania, Tel: +40-257-212204; birauamalia@yahoo.com

Read full article
Article Title: Patterns of the vascular endothelial growth factor immune-histochemical expression in lung carcinomas
Authors: Amalia Birau, Raluca Amalia Ceausu, Anca Maria Cimpean, Pusa Gaje, Gheorghe Ciobanu, Teodora Olariu, Marius Raica
Affiliation: „Vasile Goldis” Western University of Arad, Department of Intensive Care
„Vasile Goldis” Western University of Arad, Department of Radiology
”Victor Babes” University of Medicine and Pharmacy, Department of Histology, Timisoara, Romania
Abstract: Vascular endothelial growth factor (VEGF) has been demonstrated as the main angiogenic molecule in vitro and in vivo. The involvement of VEGF in the prognosis and progression of different types of tumors has been demonstrated by many publications. In the present study we have investigated the patterns of the immunohistochemical expression of VEGF in lung carcinoma. We have investigated 42 biopsies from patients admitted with different histological types of lung carcinoma. The aim of this investigation was to describe the incidence and models of distribution of the positive reaction for VEGF in lung carcinoma. The reaction for VEGF has been evaluated using a scale from 0 (negative) to 3 (strong positive), based on the percentage of positive cells. We found a strong expression for VEGF in cases with squamous cells carcinoma, adenocarcinoma and hepatoid carcinoma, and negative reaction in small cell and large cell carcinomas. Our data suggest that the incidence and intensity of VEGF expression in lung carcinoma can be a good indicator of antiangiogenic therapy based on humanized monoclonal antibody against VEGF.
Keywords: lung carcinoma, vascular endothelial growth factor (VEGF), angiogenesis
References: Aikawa H, Takahashi H, Fujimura S, Sato M, Endo C, Sakurada A, Kondo T, Tanita T, Matsumura Y, Ono S, Saito Y, Sagawa M. Immunohistochemical study on tumor angiogenic factors in non-small cell lung cancer, Anticancer Res., 1999; 19(5B):4305-9.
Bremnes R M, Carlos Camps, Rafael Sirera, Angiogenesis in non-small cell lung cancer: The prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood, Lung Cancer, 2006, 51 (2): 143-158.
Chaudhry IH, O’Donovan DG, Brenchley PE, Reid H, Roberts IS, Vascular endothelial growth factor expression correlates with tumour grade and vascularity in gliomas, Histopathology, 2001, 39(4): 409-415.
Folkman J, Merler E, Abernathy C, Williams G – Isolation of a tumor factor responsible for angiogenesis, J Exp Med. 1971, 133:275-288.
Fontanini G, Boldrini L, Vignati S, Chinè S, Basolo F, Silvestri V, Lucchi M, Mussi A, Angeletti CA, Bevilacqua G Bcl2 and p53 regulate vascular endothelial growth factor (VEGF)-mediated angiogenesis in non-small cell lung carcinoma, Eur
J Cancer. 1998, 34(5):718-723.
Inda AM, Andrini LB, García MN, García AL, Fernández Blanco A, Furnus CC, Galletti SM, Prat GD, Errecalde AL, Evaluation of angiogenesis with the expression of VEGF and CD34 in human non-small cell lung cancer, J Exp Clin Cancer Res., 2007,
26(3):375-378.
S. Ishigami, S Arii, M Furutani, M Niwano, T Harada, M Mizumoto, A Mori, H Onodera and M Imamura, Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer, Britsh Jourmal of Cancer, 1998, 78(10): 1379-1384.
Jarzynka MJ, Guo P, Bar-Joseph I, Hu B, Cheng SY., Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis, Int J Oncol., 2006, 28(2):337-344.
Li X, Zhang Q, Lu B, Qiu X, Luo Y, Zhang W, Xu S, Expression of DLL4 and VEGF in Lung Adenocarcinoma and their Relationship with Angiogenesis in Tumor, Zhongguo Fei Ai Za Zhi. 2009, 12(2):117-121.
Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z., Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 1999 Jan;13(1):9-22.
Ribatti D., The contribution of Harold F. Dvorak to the study of tumor angiogenesis and stroma generation mechanisms, Endothelium, 2007, 14(3):131-135.
Spira A, Ettinger DS. Multidisciplinary management of lung cancer. N Engl J Med 2004;350:379-392.
Toshiro Niki, Sanae Iba, Masahide Tokunou, Tesshi Yamada, Yoshihiro Matsunoand, Setsuo Hirohashi, Expression of Vascular Endothelial Growth Factors A, B, C, and D and Their Relationships to Lymph Node Status in Lung Adenocarcinoma, Clin Cancer Res, 2000, 6:2431-2439.
Tanno S, Ohsaki Y, Nakanishi K, Toyoshima E, Kikuchi K, Human small cell lung cancer cells express functional VEGF receptors, VEGFR-2 and VEGFR-3., Lung Cancer. 2004; 46(1):11-19.
Takahama M, Tsutsumi M, Tsujiuchi T, Kido A, Okajima E, Nezu K, Tojo T, Kushibe K,Kitamura S, Konishi Y. Frequent expression of the vascular endothelial growth factor in human non-small-cell lung cancers. Jpn J Clin Oncol. 1998; 28(3):176-181.
Yuan A, Yu CJ, Chen WJ, Lin FY, Kuo SH, Luh KT, Yang PC, Correlation of total VEGFmRNA and protein expression with histologic type, tumor angiogenesis, patient survival and timing of relapse in non-small-cell lung cancer., Int J Cancer., 2000;
89(6):475-483.
*Correspondence: Amalia Birau, MD, PhD student Department of Intensive Care, „Vasile Goldis” Western University of Arad, no.1 Feleacului St., Arad, Romania, Tel: +40-257-212204; birauamalia@yahoo.com