The effect of a topical treatment based on Sambuci flos extract in experimental thermal third degree skin burns

The effect of a topical treatment based on Sambuci flos extract in experimental thermal third degree skin burns

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Title: The effect of a topical treatment based on Sambuci flos extract in experimental thermal third degree skin burns
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Article_Title: The effect of a topical treatment based on Sambuci flos extract in experimental thermal third degree skin burns
Authors: George Dan Mogoşanu1, Florina Carmen Popescu2, Cristina Jana Busuioc2, Oltin Tiberiu Pop2, Horia Pârvănescu3, Ioan Lascăr4, Laurenţiu Mogoantă2*
Affiliation: 1Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy; 2Research Center for Microscopic
Morphology and Immunology; 3Department of Plastic Surgery and Reconstructive Microsurgery, University
of Medicine and Pharmacy of Craiova; 4Department of Plastic Surgery and Reconstructive Microsurgery,
“Carol Davila” University of Medicine and Pharmacy, Bucharest
Abstract: In the European ethnopharmacology, elder flowers are used external in poultices for the treatment of burns and blisters. Sambuci flos tincture was prepared and physico-chemically analyzed according to Romanian Pharmacopoeia. The soft extract, obtained from tincture, was embedded in an ointment base of cold cream type, prepared according to United States Pharmacopoeia. The study was performed on three groups of adult male Wistar rats, each of ten animals, kept under standard conditions, both before and after the burns. Skin burns from the dorsal region were treated daily as follows: cold cream with 10% Sambuci flos extract (SFE) for the first group; 1% silver sulfadiazine cream (SDA) for the second group; the third group, considered as control, received the cold cream base (CCB). The favorable evolution of burnt skin wounds in the SFE group, compared to SDA and CCB groups, is mainly due to the astringent, anti-inflammatory, antiseptic and cicatrizing action of the natural product.
Keywords: Sambuci flos, extract, cold cream, topical treatment, third degree skin burns
References: Abu-Zinadah OA, Effects of watercress oil on the thermal and chemical burn injuries in rabbits. JKAU: Med Sci, 2008, 15(4):3–17.
Atkinson MD, Atkinson E, Sambucus nigra L. J Ecology, 2002, 90(5):895–923.
Becić F, Mulabegović N, Mornjaković Z, Kapić E, Prasović S, Becić E, Kusturica J, Topical treatment of standardised burns with herbal remedies in model rats. Bosn J Basic Med Sci, 2005, 5(4):50–57.
Bojor O, Popescu O, Fitoterapie tradiţională şi modernă, ediţia a V-a revizuită şi adăugită. Ed. Fiat Lux, Bucureşti, 2009, 164, 194, 265, 344.
Bruneton J, Pharmacognosie, Phytochimie, Plantes médicinales, 4e édition, revue et augmentée. Lavoisier Tec & Doc, Paris, 2009, 436–438.
Busuioc CJ, Popescu FC, Mogoşanu GD, Lascăr I, Pirici I, Pop OT, Mogoantă L, Angiogenesis assessment in experimental third degree skin burns: a histological and immunohistochemical study. Rom J Morphol Embryol, 2011, 52(3):887–895.
Ciocârlan V, Flora ilustrată a României. Pteridophyta et Spermatophyta. Ed. Ceres, Bucureşti, 2000, 748.
Ciocoiu M, Mirón A, Mares L, Tutunaru D, Pohaci C, Groza M, Badescu M, The effects of Sambucus nigra polyphenols on oxidative stress and metabolic disorders in experimental diabetes mellitus. J Physiol Biochem, 2009, 65(3):297–304.
Forjuoh SN, Burns in low- and middle-income countries: a review of available literature on descriptive epidemiology. risk factors, treatment, and prevention. Burns, 2006, 32(5):529–537.
Han MC, Durmus AS, Karabulut E, Yaman I, Effects of Turkish propolis and silver sulfadiazine on burn wound healing in rats. Revue Méd Vét, 2005, 156(12):624–627.
Jeschke MG, Finnerty CC, Suman OE, Kulp G, Mlcak RP, Herndon DN, The effect of oxandrolone on the endocrinοlogic, inflammatory, and hypermetabolic responses during the acute phase postburn. Ann Surg, 2007, 246(3):351–360; discussion 360–362.
Kislichenko VS, Vel’ma VV, Amino-acid composition of flowers, leaves, and extract of Sambucus nigra flowers. Chem Nat Compounds, 2006, 42(1):125–126.
Kumar MS, Kirubanandan S, Sripriya R, Sehgal PK, Triphala promotes healing of infected full-thickness dermal wound. J Surg Res, 2008, 144(1):94–101.
Lamaison JL, Petitjean-Freytet C, Carnat A, Presence of isorhamnetin 3-glucoside and 3-rutinoside in Sambucus nigra L. flowers. Ann Pharm Fr, 1991, 49(5):258–262.
Popescu FC, Busuioc CJ, Mogoşanu GD, Pop OT, Pârvănescu H, Lascăr I, Nicolae CI, Mogoantă L, Pericytes and myofibroblasts reaction in experimental thermal third degree skin burns. Rom J Morphol Embryol, 2011, 52(3 Suppl):1011–1017.
Roschek B Jr, Fink RC, McMichael MD, Li D, Alberte RS, Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry, 2009, 70(10):1255–1261.
Süntar IP, Akkol EK, Yalçin FN, Koca U, Keleş H, Yesilada E, Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside. J Ethnopharmacol, 2010, 129(1):106–114.
Wagner H, Bladt Sabine, Plant drug analysis. A thin layer chromatography atlas, 2nd edition. Springer Verlag, Berlin–Heidelberg, 1996, 125–146, 195–236.
Wright CI, Van-Buren L, Kroner CI, Koning MM, Herbal medicines as diuretics: a review of the scientific evidence. J Ethnopharmacol, 2007, 114(1):1–31.
***, Farmacopeea Română ediţia a X-a. Ed. Medicală, Bucureşti, 1993, 921, 922.
***, United States Pharmacopeia–National Formulary: USP 34–NF 29. U.S. Pharmacopeial Convention, 2011.
Read_full_article: pdf/21-2011/21-4-2011/SU21-4-2011-Mogosanu.pdf
Correspondence: Laurenţiu Mogoantă, Professor, MD, PhD, Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, 2–4 Petru Rareş Street, 200349 Craiova, Romania; Phone +40251–523 654, e-mail: laurentiu_mogoanta@yahoo.com

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Article Title: The effect of a topical treatment based on Sambuci flos extract in experimental thermal third degree skin burns
Authors: George Dan Mogoşanu1, Florina Carmen Popescu2, Cristina Jana Busuioc2, Oltin Tiberiu Pop2, Horia Pârvănescu3, Ioan Lascăr4, Laurenţiu Mogoantă2*
Affiliation: 1Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy; 2Research Center for Microscopic
Morphology and Immunology; 3Department of Plastic Surgery and Reconstructive Microsurgery, University
of Medicine and Pharmacy of Craiova; 4Department of Plastic Surgery and Reconstructive Microsurgery,
“Carol Davila” University of Medicine and Pharmacy, Bucharest
Abstract: In the European ethnopharmacology, elder flowers are used external in poultices for the treatment of burns and blisters. Sambuci flos tincture was prepared and physico-chemically analyzed according to Romanian Pharmacopoeia. The soft extract, obtained from tincture, was embedded in an ointment base of cold cream type, prepared according to United States Pharmacopoeia. The study was performed on three groups of adult male Wistar rats, each of ten animals, kept under standard conditions, both before and after the burns. Skin burns from the dorsal region were treated daily as follows: cold cream with 10% Sambuci flos extract (SFE) for the first group; 1% silver sulfadiazine cream (SDA) for the second group; the third group, considered as control, received the cold cream base (CCB). The favorable evolution of burnt skin wounds in the SFE group, compared to SDA and CCB groups, is mainly due to the astringent, anti-inflammatory, antiseptic and cicatrizing action of the natural product.
Keywords: Sambuci flos, extract, cold cream, topical treatment, third degree skin burns
References: Abu-Zinadah OA, Effects of watercress oil on the thermal and chemical burn injuries in rabbits. JKAU: Med Sci, 2008, 15(4):3–17.
Atkinson MD, Atkinson E, Sambucus nigra L. J Ecology, 2002, 90(5):895–923.
Becić F, Mulabegović N, Mornjaković Z, Kapić E, Prasović S, Becić E, Kusturica J, Topical treatment of standardised burns with herbal remedies in model rats. Bosn J Basic Med Sci, 2005, 5(4):50–57.
Bojor O, Popescu O, Fitoterapie tradiţională şi modernă, ediţia a V-a revizuită şi adăugită. Ed. Fiat Lux, Bucureşti, 2009, 164, 194, 265, 344.
Bruneton J, Pharmacognosie, Phytochimie, Plantes médicinales, 4e édition, revue et augmentée. Lavoisier Tec & Doc, Paris, 2009, 436–438.
Busuioc CJ, Popescu FC, Mogoşanu GD, Lascăr I, Pirici I, Pop OT, Mogoantă L, Angiogenesis assessment in experimental third degree skin burns: a histological and immunohistochemical study. Rom J Morphol Embryol, 2011, 52(3):887–895.
Ciocârlan V, Flora ilustrată a României. Pteridophyta et Spermatophyta. Ed. Ceres, Bucureşti, 2000, 748.
Ciocoiu M, Mirón A, Mares L, Tutunaru D, Pohaci C, Groza M, Badescu M, The effects of Sambucus nigra polyphenols on oxidative stress and metabolic disorders in experimental diabetes mellitus. J Physiol Biochem, 2009, 65(3):297–304.
Forjuoh SN, Burns in low- and middle-income countries: a review of available literature on descriptive epidemiology. risk factors, treatment, and prevention. Burns, 2006, 32(5):529–537.
Han MC, Durmus AS, Karabulut E, Yaman I, Effects of Turkish propolis and silver sulfadiazine on burn wound healing in rats. Revue Méd Vét, 2005, 156(12):624–627.
Jeschke MG, Finnerty CC, Suman OE, Kulp G, Mlcak RP, Herndon DN, The effect of oxandrolone on the endocrinοlogic, inflammatory, and hypermetabolic responses during the acute phase postburn. Ann Surg, 2007, 246(3):351–360; discussion 360–362.
Kislichenko VS, Vel’ma VV, Amino-acid composition of flowers, leaves, and extract of Sambucus nigra flowers. Chem Nat Compounds, 2006, 42(1):125– 126.
Kumar MS, Kirubanandan S, Sripriya R, Sehgal PK, Triphala promotes healing of infected full-thickness dermal wound. J Surg Res, 2008, 144(1):94–101.
Lamaison JL, Petitjean-Freytet C, Carnat A, Presence of isorhamnetin 3-glucoside and 3-rutinoside in Sambucus nigra L. flowers. Ann Pharm Fr, 1991, 49(5):258–262.
Popescu FC, Busuioc CJ, Mogoşanu GD, Pop OT, Pârvănescu H, Lascăr I, Nicolae CI, Mogoantă L, Pericytes and myofibroblasts reaction in experimental thermal third degree skin burns. Rom J Morphol Embryol, 2011, 52(3 Suppl):1011–1017.
Roschek B Jr, Fink RC, McMichael MD, Li D, Alberte RS, Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry, 2009, 70(10):1255–1261.
Süntar IP, Akkol EK, Yalçin FN, Koca U, Keleş H, Yesilada E, Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside. J Ethnopharmacol, 2010, 129(1):106–114.
Wagner H, Bladt Sabine, Plant drug analysis. A thin layer chromatography atlas, 2nd edition. Springer Verlag, Berlin–Heidelberg, 1996, 125–146, 195–236.
Wright CI, Van-Buren L, Kroner CI, Koning MM, Herbal medicines as diuretics: a review of the scientific evidence. J Ethnopharmacol, 2007, 114(1):1–31.
***, Farmacopeea Română ediţia a X-a. Ed. Medicală, Bucureşti, 1993, 921, 922.
***, United States Pharmacopeia–National Formulary: USP 34–NF 29. U.S. Pharmacopeial Convention, 2011.
*Correspondence: Laurenţiu Mogoantă, Professor, MD, PhD, Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, 2–4 Petru Rareş Street, 200349 Craiova, Romania; Phone +40251–523 654, e-mail: laurentiu_mogoanta@yahoo.com