Relation between peritoneal aggression and fibrinolysis

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Article Title:	Relation between peritoneal aggression and fibrinolysis
Authors:	Sebastian Gradinaru Fometescu1, Costel Savlovschi1, Marieta Costache2, Sorin Mircea Oprescu1
Affiliation:	1 University Emergency Hospital Bucharest, 4th Department of Surgery, Romania 2 University of Bucharest, Department of Biochemistry and Molecular Biology, Romania
Abstract:	The triggering of the formation of adhesions is caused by the organization of the fibrin matrix, an organization that takes place during the coagulation processes when there is suppression of fibrinolysis. In this study two groups of patients are analyzed First group was used, both for evidencing the peritoneal fibrinolytic activity by determining the fibrinogen and the fibrin degradation products (FDP) in the peritoneal liquid and for extract the tPA and PAI-1 from the peritoneal tissue. The second group is the control group in whose cases none of the aggression factors (traumatic, chemical, bacterial) noticed in the patients of the first group was proven to exist. The aim of this study was to evaluate the role of PAI-1 and tPA genes at peritoneal tissue level. Peritoneal tissue was obtained during surgery and we have quantified the variation of expression of PAI-1 and tPA genes. The obtained results highlight an increase of expression in PAI-1 gene and decrease of expression in tPA gene, which indicated an decrease fibrinolytic potential.
Keywords:	adhesions, fibrinolysis, fibrin, tPA, PAI-1
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*Correspondence:	Marieta Costache, marietacostache@yahoo.com; costache@bio.unibuc.ro