Case study on sudden cardiac death

October 17, 2010

Case study on sudden cardiac death

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Article_Title:	Case study on sudden cardiac death
Authors:	Ovidiu Bulzan1, George Ciprian Pribac2
Affiliation:	1 County Emergency Clinic Hospital Arad, Department of Forensic Medicine 2”Vasile Goldis” Western University Arad, Department of Cell and Molecular Biology
Abstract:	Sudden cardiac death occurs, according to WHO within an hour after the onset of the first symptoms. According to the recommendations of the European Society of Cardiology, sudden cardiac death is defined as, “natural death due to cardiac causes, announced by the sudden loss of consciousness within one hour after the debut of acute symptomatology; the pre-existing heart disease may be known but when and how death appears is unexpected. The study aims to find correlations between data history, age, sex, macroscopic diagnosis and anatomical substrate (materialized by microscopic histological examination, following that in the next steps of the experiment to complete our research with molecular investigations on archived histological samples). Of the 22 autopsies, the case of a man of 40 years, draw our attention, a man who died at home with witnesses, in the absence of premonitory symptoms or paraclinical elements and whose health status was regularly checked by the nature of his job. Forensic autopsy could not detect certain gross morphological changes in the heart.
Keywords:	sudden death, microscopic analysis, molecular analysis
References:	Shaper AG, Wannamethee G, Macfarlane PW, Walker M. Heart rate, ischaemic heart disease, and sudden cardiac death in middle-aged British men. Br Heart J 1993; 70: 49-55. Eur heart J. Vol 22, issue 16, August 2001. Haider AW, Larson MG, Benjamin EJ, Levy D. Increased left ventricular mass and hypertrophy are associated with increased risck for dudden death. J Am Coll Cardiol 1998; 32: 1454-9. Kors JA, de Bruyne MC, Hoes Awet al. T-loop morphology as a marker of cardiac events in the ederly. J Electrocardiol 1998; 31(Suppl): 54-9. Burton F, Cobbe SM. Dispersion of ventricular repolarization and refractoriness. Cardiovas Res 2001; 50: 10-23. Elliot PM, Poloniecki J, Dickie S et al. Sudden death in hypertrophic cardiomyopathy: identification of high risk patients. J Am Coll Cardiol 2000; 36: 2212-6.Berger R.: Circulation. 2002; 105: 2392-2397. Veinot JP, Gattinger DA, Fliss H.: Early apoptosis in human myocardial infarcts. Hum Pathol 28(4): 485-492(1997). Sholler GF, Walsh EP. Congenital complete hearth block in patients without anatomic cardiac defects. Am Hearth J 1989; 118: 1193-8. Maron BJ. Sudden death in young athletes. Lesson from the Hank Gathers a. air. N Engl J Med 1993; 329: 55-7. Maron BJ. Cardiovascular risks to young person on the athletic field. Ann Intern Med 1998; 129: 378-86. Beranek JT: Pathogenesis of hearth fibrosis in systemic sclerosis. Int J Cardiol 2001, 80: 261-262. Blagy H, et al: Serum BNP, hs-C-reactive protein, procollagen to assess the risk of ventricular tachycardia in ICD recipients after myocardial infarction, Europace.2007 Sep; 9(9): 724-9.Epub 2007 May 24. Narula, J et al.: Apoptosis in myocytes in end-stages heart failure, N Engl J Med 335(16): 1182-1189(1997). Pfister GC, Pu.er JC, Maron BJ. Preparticipation cardiovascular screening for collegiate student-athletes. JAMA 2000; 283: 1597-9. Dermengiu D., Ceusu M., Rusu M.C., S. Dermengiu., Curcă G.C., Hostiuc S. Sudden death assdociated with borderline Hypertrophic cardiomiopathy and multiple coronary anomalies. Case report and literature review, RJLM vol. XVIII, nr. 1, march 2010, pg. 3-13. Michaud K., Lesta M.D.M., Fellman F., Mangin P., L’autopsie moleculaire de la mort subite cardiaque : de la salle d’autopsie au cabinet du praticien, Revue Medicale Suisse, 2 juillet 2008, no 164, vol 4, 1585-1632, ISSN 1660-9379. Beranek JT: Why primary angioplasty is less offensive to the myocardium compared with thrombolysis for acute myocardial infarction. Am heart J 2000. Myerburg, Robert J. ,,Cardiac Arrest and Sudden Cardiac Death” in Heart Disease: A Textbook of Cardiovascular Medicine, 7 thedition. Philadelphia: WB Saunders, 2005. Dermengiu Dan. Curs de medicină legală. Editura Viaţa Medicală Românească, Bucureşti 2005, 26-53. Curcă GC, Drugescu N., Ardeleanu C., Ceauşu M.: Repere de investigare în moartea subită cardiacă la adultul tânăr, Rom J LegMed 16(1)57, 2008, 57-66. Robert J Myerburg, Agustin Castellanos: Cardiac Arrest and Suden Cardiac Death: 26; 890-909. 2001.
Read_full_article:	pdf/20-2010/20-2-2010/SU20-2-10Bulzan.pdf
Correspondence:	George Pribac, Faculty of Medcine, Pharmacy and Dental Medicine, “Vasile Goldis” Western University Arad, no. 1 Feleacului St., Arad, Romania, E-mail: georgepribac@gmail.com

	Read full article
Article Title:	Case study on sudden cardiac death
Authors:	Ovidiu Bulzan1, George Ciprian Pribac2
Affiliation:	1 County Emergency Clinic Hospital Arad, Department of Forensic Medicine 2”Vasile Goldis” Western University Arad, Department of Cell and Molecular Biology
Abstract:	Sudden cardiac death occurs, according to WHO within an hour after the onset of the first symptoms. According to the recommendations of the European Society of Cardiology, sudden cardiac death is defined as, “natural death due to cardiac causes, announced by the sudden loss of consciousness within one hour after the debut of acute symptomatology; the pre-existing heart disease may be known but when and how death appears is unexpected. The study aims to find correlations between data history, age, sex, macroscopic diagnosis and anatomical substrate (materialized by microscopic histological examination, following that in the next steps of the experiment to complete our research with molecular investigations on archived histological samples). Of the 22 autopsies, the case of a man of 40 years, draw our attention, a man who died at home with witnesses, in the absence of premonitory symptoms or paraclinical elements and whose health status was regularly checked by the nature of his job. Forensic autopsy could not detect certain gross morphological changes in the heart.
Keywords:	sudden death, microscopic analysis, molecular analysis
References:	Shaper AG, Wannamethee G, Macfarlane PW, Walker M. Heart rate, ischaemic heart disease, and sudden cardiac death in middle-aged British men. Br Heart J 1993; 70: 49-55. Eur heart J. Vol 22, issue 16, August 2001. Haider AW, Larson MG, Benjamin EJ, Levy D. Increased left ventricular mass and hypertrophy are associated with increased risck for dudden death. J Am Coll Cardiol 1998; 32: 1454-9. Kors JA, de Bruyne MC, Hoes Awet al. T-loop morphology as a marker of cardiac events in the ederly. J Electrocardiol 1998; 31(Suppl): 54-9. Burton F, Cobbe SM. Dispersion of ventricular repolarization and refractoriness. Cardiovas Res 2001; 50: 10-23. Elliot PM, Poloniecki J, Dickie S et al. Sudden death in hypertrophic cardiomyopathy: identification of high risk patients. J Am Coll Cardiol 2000; 36: 2212-6.Berger R.: Circulation. 2002; 105: 2392-2397. Veinot JP, Gattinger DA, Fliss H.: Early apoptosis in human myocardial infarcts. Hum Pathol 28(4): 485-492(1997). Sholler GF, Walsh EP. Congenital complete hearth block in patients without anatomic cardiac defects. Am Hearth J 1989; 118: 1193-8. Maron BJ. Sudden death in young athletes. Lesson from the Hank Gathers a. air. N Engl J Med 1993; 329: 55-7. Maron BJ. Cardiovascular risks to young person on the athletic field. Ann Intern Med 1998; 129: 378-86. Beranek JT: Pathogenesis of hearth fibrosis in systemic sclerosis. Int J Cardiol 2001, 80: 261-262. Blagy H, et al: Serum BNP, hs-C-reactive protein, procollagen to assess the risk of ventricular tachycardia in ICD recipients after myocardial infarction, Europace.2007 Sep; 9(9): 724-9.Epub 2007 May 24. Narula, J et al.: Apoptosis in myocytes in end-stages heart failure, N Engl J Med 335(16): 1182-1189(1997). Pfister GC, Pu.er JC, Maron BJ. Preparticipation cardiovascular screening for collegiate student-athletes. JAMA 2000; 283: 1597-9. Dermengiu D., Ceusu M., Rusu M.C., S. Dermengiu., Curcă G.C., Hostiuc S. Sudden death assdociated with borderline Hypertrophic cardiomiopathy and multiple coronary anomalies. Case report and literature review, RJLM vol. XVIII, nr. 1, march 2010, pg. 3-13. Michaud K., Lesta M.D.M., Fellman F., Mangin P., L’autopsie moleculaire de la mort subite cardiaque : de la salle d’autopsie au cabinet du praticien, Revue Medicale Suisse, 2 juillet 2008, no 164, vol 4, 1585-1632, ISSN 1660-9379. Beranek JT: Why primary angioplasty is less offensive to the myocardium compared with thrombolysis for acute myocardial infarction. Am heart J 2000. Myerburg, Robert J. ,,Cardiac Arrest and Sudden Cardiac Death” in Heart Disease: A Textbook of Cardiovascular Medicine, 7 thedition. Philadelphia: WB Saunders, 2005. Dermengiu Dan. Curs de medicină legală. Editura Viaţa Medicală Românească, Bucureşti 2005, 26-53. Curcă GC, Drugescu N., Ardeleanu C., Ceauşu M.: Repere de investigare în moartea subită cardiacă la adultul tânăr, Rom J LegMed 16(1)57, 2008, 57-66. Robert J Myerburg, Agustin Castellanos: Cardiac Arrest and Suden Cardiac Death: 26; 890-909. 2001.
*Correspondence:	George Pribac, Faculty of Medcine, Pharmacy and Dental Medicine, “Vasile Goldis” Western University Arad, no. 1 Feleacului St., Arad, Romania, E-mail: georgepribac@gmail.com

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