Triadic integration of the microbiome, lymphatic system, and the psyche: a narrative integrative review and conceptual framework for neuroimmune health
May 6, 2026
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| Article Title: | Triadic integration of the microbiome, lymphatic system, and the psyche: a narrative integrative review and conceptual framework for neuroimmune health |
| Authors: | Cojocaru M., Grigorescu C.C., Grigorescu M.Ș., Tihan E.J. |
| Affiliation: | Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania Faculty of Medicine, Vasile Goldiș University, Arad, Romania Faculty of Medicine, Victor Babeș University of Medicine and Pharmacy, Timisoara, Romania Tihan & Associates. Professional Civil Society for Psychology, Bucharest, Romania |
| Abstract: | Psychoneuroimmunology reveals complex bidirectional interactions between the intestinal microbiome, immune signaling, and psychological processes, with the mesenteric lymphatic system emerging as a critical but underexplored mediator. This systematic review (PRISMA 2020, 94 synthesized studies) confirms a triadic interaction where psychological stress alters gut permeability and lymphatic flow, while dysbiosis and lymph-borne inflammatory mediators drive neuroinflammation and behavioral symptoms. Mast cells act as key neuroimmune transducers. Eating disorders exemplify this dysregulation. The proposed framework integrates biological and psychological dimensions, supporting integrative treatments combining psychotherapy, nutrition, and phytotherapy to restore systemic balance, though clinical validation is required. |
| Keywords: | intestinal microbiome, mesenteric lymphatic system, psychoneuroimmunology, mast cells, integrative phytotherapy. |
| *Correspondence: | Grigorescu Maxim Șerban, Faculty of Medicine, Victor Babeș University of Medicine and Pharmacy, Timisoara, Romania, email: serban@grigorescu.pro |
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