Possible protective effect of algerian Ephedra alata subsp. Alenda (stapf) trab extract against fenthion-induced histopathological and biochemical alteration in rat
November 17, 2025
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| Article Title: | Possible protective effect of algerian Ephedra alata subsp. Alenda (stapf) trab extract against fenthion-induced histopathological and biochemical alteration in rat |
| Authors: | Djaalali I., Guedri K., Berroukeche F., Messaadia A., Gasmi S., Attoui N., Tayaa H. |
| Affiliation: | Laboratory of Bioactive molecules and applications, Faculty of Exact Sciences and Nature and Life Sciences, university Echahid Cheikh Larbi Tebessi University, Tebessa 12002 Algeria; ilhem.djaalali@univ-tebessa.dz Laboratory of Toxicology and Ecosystems Pathologies, Faculty of Exact Sciences and Nature and Life Sciences, university Echahid Cheikh Larbi Tebessi University, Tebessa 12002 Algeria; guedrikamilia@yahoo.fr Laboratory of Physiology, Pathophysiology, and Biochemistry of Nutrition, Department of Biology, Faculty of Nature and Life Sciences, Earth and Universe, University of Tlemcen 13000, Algeria; biotoxicologie@yahoo.fr Department of biology, Faculty science of nature and life, Laboratory of Vegetal Resources Valorization and Food Security in Semi-Arid Areas South West of Algeria. Tahri Mohamed University of Bechar, Algeria; attouinawel@yahoo.fr AbdelHafid Boussouf university of Mila, Algeria; tayaa.hakima@yahoo.fr |
| Abstract: | Ephedra alata subsp alenda (Stapf) Trab, is an endemic plant of the Algerian Sahara. In this study, we sought to investigate the possible preventive effect of plant extract against hepatotoxicity induced by fenthion in male Wistar rats. For this purpose, 40 albinos male rats were randomly divided into four groups.The first group received orally 1.5 ml of corn oil serving as a control; the second group were treated by 1 mg/kg/d of fenthion; group 3 received 300 mg/kg/d of E. alata extract; and the 4th group received both fenthion and ephedra. 30 days later, rats were sacrificed, Blood samples were collected for hematological and biochemical estimation, and liver fragments were reserved to assess antioxidant activity and histopathological examination. Our results showed that exposure to fenthion caused decrease in body weight, and induced biochemical disturbances characterized by hyperglycemia, hyperlipidemia, leukocytosis, and significant increase in hepatic biomarkers accompanied by increase in liver relative weight. In the oxidative stress profile, we found that MDA activity increased, while GSH level, GST and CAT activities decreased. Furthermore, fenthion showed histological damage in liver tissue. Otherwise, addition of E. alata notably allows to restore most of the parameters measured in this study. These results suggest that the studied dose of E. alata had antioxidant activity and hepatoprotective effect against fenthion toxicity in male rats. |
| Keywords: | Ephedra alata alenda, fenthion, oxidative stress, toxicity, liver. |
| *Correspondence: | Kamilia Guedri, Laboratory of Toxicology and Ecosystems Pathologies, Faculty of Exact Sciences and Nature and Life Sciences, university Echahid Cheikh Larbi Tebessi University, Tebessa 12002 Algeria, Tel: (213)550305321, email: guedrikamilia@yahoo.fr |
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