Ethnopharmacology and candida-inhibitory effects of Xylopia aethiopica (Annonaceae) fruit extracts: synergistic enhancement with miconazole
May 28, 2026
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| Article Title: | Ethnopharmacology and candida-inhibitory effects of Xylopia aethiopica (Annonaceae) fruit extracts: synergistic enhancement with miconazole |
| Authors: | Kozolina T., Kola P., Obistioiu D., Floares D., Hulea A., Diallo A., Bakoma B., Stroia C., Imbrea I. |
| Affiliation: | Laboratory of Pharmaceutical Sciences, Faculty of Health Sciences, Doctoral school ED732-STIS, University of Lome, 01 BP: 1515, Lome, Togo Laboratory of Applied Agronomic and Biological Sciences (LaSABA), Faculty of Sciences and Techniques, University of Kara, BP: 404, Kara, Togo University of Life Sciences “King Michael I” from Timisoara, Calea Aradului 119, 300645 Timisoara, Romania Department of Pharmacy, Laboratory of Pharmacology-Toxicology, Faculty of Health Sciences, University of Lomé, BP: 1515, Lome, Togo Department of Pharmacy, Laboratory of Pharmaceutical Sciences, Faculty of Health Sciences, University of Lomé, BP: 1515, Lome, Togo |
| Abstract: | An ethnopharmacological survey was conducted involving 203 participants in the Central Region of Togo. We assessed the anti-Candida activity and the ability of hydroalcoholic extracts and essential oils, obtained through hydrodistillation and steam distillation, to enhance the effectiveness of miconazole. This evaluation was performed using the microdilution method and optical density measurements against Candida albicans and Candida parapsilosis. The survey identified 30 disorders, with gynecological and obstetrical issues being the most prevalent at 90.14%. The essential oils achieved mycelial inhibition percentages exceeding 70% at a concentration of 8 mg/mL, indicating a clear dose-dependent effect. Among the hydroalcoholic extracts, the hydromethanolic extract (1:2) exhibited the most promising antifungal activity against the tested Candida strains. Furthermore, essential oils obtained through hydrodistillation exhibited a synergistic effect when combined with miconazole. Xylopia aethiopica essential oils are more potent than solvent extracts and could serve as promising natural adjuvants for treating fungal infections. |
| Keywords: | boosted, Candida, ethnomedicinal, microdilution, Togo, Xylopia aethiopica. |
| *Correspondence: | Ilinca Imbrea, University of Life Sciences “King Michael I” from Timisoara, Calea Aradului 119, 300645 Timișoara, Romania., email: ilinca_imbrea@usvt.ro |
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