Assessment of behavioral and physiological responses in Wistar Rats exposed to Hyoscyamus albus L.
February 17, 2026
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| Article Title: | Assessment of behavioral and physiological responses in Wistar Rats exposed to Hyoscyamus albus L. |
| Authors: | Boublata N.E.I., Habbachi S., Tabirca A.I., Djaouhadou R., Habbachi W., Rebbas K., Tahraoui A. |
| Affiliation: | Laboratory of Applied Neuroendocrinology. Badji Mokhtar – Annaba University P.O Box.12, Annaba-23000 Algeria Faculty of Economics, Valahia University of Targoviste, 130004 Targoviste, Romania Research Laboratory in Innovation and Economic and Financial Analysis. Badji Mokhtar – Annaba University P.O Box.12, Annaba-23000 Algeria Laboratory of Agro-biotechnology and Nutrition in arid and semi-arid zones, Ibn Khaldoun University, Tiaret, Algeria Department of Biology, Faculty of Science-Université Med Boudiaf, M’Sila 28000 |
| Abstract: | Hyoscyamus albus L. (Solanaceae) is a medicinal plant traditionally used for its sedative and parasympatholytic properties and contains flavonoids, alkaloids, and tropane derivatives. This study evaluated the effects of aqueous extracts from the aerial parts of H. albus, collected in the M’sila region (Algeria), on biochemical, hormonal, and behavioral parameters in Wistar rats. Animals received 1 mL/day of extract (292 g/L) orally for seven consecutive days. Biochemical analyses revealed significant changes in blood glucose, cholesterol, triglycerides, urea, and creatinine, including hypoglycemia and reduced cholesterol levels in treated animals. Plasma adrenocorticotropic hormone (ACTH) was also significantly modulated. Behavioral assessments using the open field, elevated plus maze, and forced swimming tests showed a clear reduction in anxiety-like behavior. These findings indicate that H. albus aqueous extract exerts both anxiolytic and metabolic effects, supporting its traditional use and highlighting potential therapeutic applications. |
| Keywords: | Hyoscyamus albus L, Solanaceae, anxiolytic, behaviour, biochemistry. |
| *Correspondence: | Nour El Imène Boublata, Laboratory of Applied Neuroendocrinology. Badji Mokhtar – Annaba University P.O Box.12, Annaba-23000 Algeria, phone number: +213 (0) 540 90 91 01, email: nour-el-imene.boublata@univ-annaba.dz |
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