Evaluation of the mitodepressive effect of Hypericum haplophylloides subsp devollense extracts
December 18, 2025
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| Article Title: | Evaluation of the mitodepressive effect of Hypericum haplophylloides subsp devollense extracts |
| Authors: | Pajenga E., Vishkulli S S., Serica R. |
| Affiliation: | Department of Biology, Faculty of Natural Science, University of Elbasan “A.Xhuvani”, Albania Department of Industrial Chemistry, Faculty of Natural Science, University of Tirana, Albania |
| Abstract: | Although numerous species within the genus Hypericum have been investigated for their biological and ethnopharmacological activities, the cytotoxic and genotoxic profiles of the endemic Hypericum haplophylloides subsp. devollense (HHD) have not yet been characterized. The present study assessed the extract’s mitodepressive effects, its capacity to inhibit primary root elongation, and the range of chromosomal aberrations induced by three aqueous extract concentrations (2000, 4000, and 8000 mg/mL), utilizing the Allium cepa model as a sensitive and widely accepted cytogenotoxicity assay. The results showed a concentration-dependent decline in the mitotic index and root tip length. Chromosomal abnormalities frequency —such as laggard chromosomes, sticky, c-mitosis, anaphase bridges decreased at higher concentrations. Overall, HHD exhibited clear antiproliferative activity with higher concentration, inducing only minimal genotoxic effects. |
| Keywords: | mitodepressive, genotoxic, root elongation, Hypericum haplophylloides subsp. devollense, Allium cepa. |
| *Correspondence: | Edlira Pajenga, Department of Biology, Faculty of Natural Science, University of Elbasan “A.Xhuvani”, Street “Ismail Zyma”, Elbasan, Abania, email: edlira.pajenga@uniel.edu.al |
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