Effects of aqueous and ethanolic extracts of Ruta chalepensis (sapindales: rutaceae) on Wistar rats
November 26, 2025
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| Article Title: | Effects of aqueous and ethanolic extracts of Ruta chalepensis (sapindales: rutaceae) on Wistar rats |
| Authors: | Cheddad R., Boublata N.E.I., Hamida Y.I., Habbachi W., Djaouahdou R., Tabirca A.I., Radu V. |
| Affiliation: | Laboratoiry of Applied Neuroendocrinology. Department of Biology, Faculty of Sciences, University BadjiMokhtar Annaba 23000, Algeria Faculty of Economics, Commerce & Management, University BadjiMokhtar Annaba 23000, Algeria Faculty of Economics, Valahia University of Targoviste, 130004 Targoviste, Romania |
| Abstract: | The use of plant-based biopesticides is considered a promising alternative to chemical pesticides for human health. In this study, we investigated the effects of aqueous and ethanolic extracts of Ruta Chalepensis leaves. Experiments were conducted on Wistar rats (Rattus rattus), widely used as a model in pharmacology and toxicology. The extracts were administered orally for seven consecutive days. To evaluate anxiety-related behavior, three standard tests were performed: the open field, the elevated plus maze, and the forced swim test. Results showed that the extracts produced no significant behavioral changes. However, biochemical analyses revealed modifications in urea and blood glucose levels, while creatinine, cholesterol, and triglycerides remained unchanged. Hematological tests indicated a reduction in red blood cell count. In contrast, other blood parameters such as white blood cells, hemoglobin, and platelets were not affected. These findings suggest that Ruta Chalepensis may influence certain biochemical and hematological markers without altering behavior in rats. |
| Keywords: | biopesticide, Ruta chanlepnsis L, Wistar rat, aqueous extract, ethanolic extract. |
| *Correspondence: | Rayene Cheddad, Laboratoiry of Applied Neuroendocrinology. Department of Biology, Faculty of Sciences, University BadjiMokhtar Annaba 23000, Algeria, phone number: +213 (0) 664 80 10 83, email: rayenecheddad@gmail.com |
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