Effects of aqueous and ethanolic extracts of Ruta chalepensis (sapindales: rutaceae) on Wistar rats
November 26, 2025
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| Article Title: | AAAAAAEffects of aqueous and ethanolic extracts of Ruta chalepensis (sapindales: rutaceae) on Wistar rats |
| Authors: | Cheddad R., Boublata N.E.I., Hamida Y.I., Habbachi W., Djaouahdou R., Tabirca A.I., Radu V. |
| Affiliation: | Laboratoiry of Applied Neuroendocrinology. Department of Biology, Faculty of Sciences, University BadjiMokhtar Annaba 23000, Algeria Faculty of Economics, Commerce & Management, University BadjiMokhtar Annaba 23000, Algeria Faculty of Economics, Valahia University of Targoviste, 130004 |
| Abstract: | , is an endemic plant of the Algerian Sahara. In this study, we sought to investigate the possible preventive effect of plant extract against hepatotoxicity induced by fenthion in male Wistar rats. For this purpose, 40 albinos male rats were randomly divided into four groups.The first group received orally 1.5 ml of corn oil serving as a control; the second group were treated by 1 mg/kg/d of fenthion; group 3 received 300 mg/kg/d of E. alata extract; and the 4th group received both fenthion and ephedra. 30 days later, rats were sacrificed, Blood samples were collected for hematological and biochemical estimation, and liver fragments were reserved to assess antioxidant activity and histopathological examination. Our results showed that exposure to fenthion caused decrease in body weight, and induced biochemical disturbances characterized by hyperglycemia, hyperlipidemia, leukocytosis, and significant increase in hepatic biomarkers accompanied by increase in liver relative weight. In the oxidative stress profile, we found that MDA activity increased, while GSH level, GST and CAT activities decreased. Furthermore, fenthion showed histological damage in liver tissue. Otherwise, addition of E. alata notably allows to restore most of the parameters measured in this study. These results suggest that the studied dose of E. alata had antioxidant activity and hepatoprotective effect against fenthion toxicity in male rats. |
| Keywords: | Ep alenda, fenthion, oxidative stress, toxicity, liver. |
| *Correspondence: | Kamilia Guedri, Laboratory of Toxicology and Ecosystems Pathologies, Faculty of Exact Sciences and Nature and Life Sciences, university Echahid Cheikh Larbi Tebessi University, Tebessa 12002 Algeria, Tel: (213)550305321, email: guedrikamilia@yahoo.fr |
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