Gemmotherapy extracts with quercetin and its derivatives
November 20, 2025
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| Article Title: | Gemmotherapy extracts with quercetin and its derivatives |
| Authors: | Chișe E., Olah N.-K., Burtescu R.F., Hanganu D., Mirel S., Dărăban A., Hepcal Cuc I., Jolji M., Héjja M., Bota V.B., Máthé E., Turcuș V. |
| Affiliation: | Faculty of Pharmacy, “Vasile Goldiș” Western University of Arad, 310048, Romania SC PlantExtrakt SRL, Rădaia, Cluj, 407059, Romania Department of Pharmacognosy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca 400010, Romania Department of Biology, “Vasile Goldiș” Western University of Arad, 310048, Romania National Institute for Economic Research “Costin C. Kiritescu” of the Romanian Academy/ Centre for Mountain Economy (CE-MONT), Vatra Dornei, Romania Institute of Nutrition, University of Debrecen, H-4032, Hungary |
| Abstract: | Quercetin is one of the most common polyphenol worldwide, named after the oak forest – quercetum. It is considered one of the most powerful antioxidants due to its five phenolic groups, respectively, the ɣ-pyrone cycle. This flavonoid and its glycosylated derivatives, such as rutoside, hyperoside, quercitrin, and iso-quercitrin, are also present in the extracts obtained from the buds and young shoots of different species, extracts that are therapeutic tools for the new branch of phytotherapy named gemmotherapy or meristem-therapy. In the pandemic context the quercetin and its derivatives were successfully used to improve the side/late effects of SARS-CoV-2 infection. Our study involved the extracts from buds of hazel (Corylus avellana), sweet chestnut (Castanea sativa), and the young shoots from honeysuckle (Lonicera nigra), dog-rose (Rosa canina), lingonberry (Vaccinium vitis-idaea), and European blackberry (Rubus fruticosus). Quercetin and its derivatives were identified and quantified by the HPLC method. The total flavonoids were determined by the spectral method. The highest quercetin-containing gemmotherapy extracts were obtained from the sweet chestnut and hazel buds, respectively, from Honeysuckle and Lingonberry young shoots. Due to their rich quercetin content, these extracts were proposed for the complementary treatment of SARS-CoV-2 infections and post-COVID symptoms. |
| Keywords: | quercetin, gemmotherapy extracts, Hazel buds, Sweet chestnut buds, Honeysuckle young shoots, Lingonberry young shoots, SarsCov-2 infection. |
| *Correspondence: | Violeta Turcuș, Department of Biology, “Vasile Goldiș” Western University of Arad, 310048, Romania, email: violeta_buruiana@yahoo.com; Daniela Hanganu, Department of Pharmacognosy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca 400010, Romania, email: dhanganu@umfcluj.ro |
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