The immunohistochemical study of endometrial and endocervical carcinomas using anti-vimentin in…

The immunohistochemical study of endometrial and endocervical carcinomas using anti-vimentin in…

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Title: The immunohistochemical study of endometrial and endocervical carcinomas using anti-vimentin in…
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Article_Title: The immunohistochemical study of endometrial and endocervical carcinomas using anti-vimentin in coexpression with anti-ER
Authors: Adriana Radu, Corina D. Frandes, O. Pop, Mircea Sferdian, L.D. Stretcu
Affiliation: “Vasile Goldis” Western University of Arad, Romania
Faculty of Medicine, Pharmacy and Dental Medicine
Abstract: The uterus is the organ from which numerous epithelial and mesenchymal tumours originate, some of which arise many difficulties when it comes to differential diagnosis. Immunohistochemistry is an important part of the differential diagnosis between endometrial versus endocervical adenocarcinoma, as well as in identifying precursor lesions. Microscopically the two locations present different histopathological varieties. Within our study we analysed the histological characters and immunohistochemical profiles of the endometrioid type of cancer. In the hereby study, the immunohistochemical marking was made using the following monoclonal antibodies: anti – vimentin, anti-estrogenic receptor and progesteronic anti receptor.
Keywords: adenocarcinoma, endometrium, endocervix, vimentin, ER/PR
References: Soslow R.A., Isacson C., Diagnostic immune-histochemistry of the female genital tract, în: Dabbs DJ: Diagnostic Immunohistochemistry, Churchill Livingstone, Philadelphia: 486-516, 2002.
Soslow R.A., Isacson C., Zaloudek C., Immuno-histopathology of the female genital tract In: Dabbs D, Diagnostic immunohistochemestry, ED DJ Dabbs second edi Churchill Livingstone Elsevier, 2006.
Sternberg S. S., Diagnostic Surgical Pathology, Raven Press, 1994, vol. 2.
Frandes D.C., Contributii la corelatiile morfo-fiziologice la nivel placentar in prematuritate si tulburari de dezvoltare, 2003.
McCluggage W.G., Recent advances in immune-histochemistry in gynaecological pathology, Histopathology.; 40(4):309-26, 2002.
McCluggage W.G., Sumathi V.P., McBride H.A., Patterson A., A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin, and estrogen receptor, aids the distinction between primary endometrial and endocervical adenocarcinomas. Int J Gynecol Pathol 21:11-15, 2002.
Read_full_article: pdf/20-2010/20-3-2010/SU20-3-10Radu.pdf
Correspondence: Adriana Radu, Faculty of Medicine, Pharmacy and Dental Medicine,”Vasile Goldiş” Western University, Arad,310396, no. 94-96 Revolutiei Bd., Arad, Romania, E-mail: medicina@uvvg.ro

Read full article
Article Title: The immunohistochemical study of endometrial and endocervical carcinomas using anti-vimentin in coexpression with anti-ER
Authors: Adriana Radu, Corina D. Frandes, O. Pop, Mircea Sferdian, L.D. Stretcu
Affiliation: “Vasile Goldis” Western University of Arad, Romania
Faculty of Medicine, Pharmacy and Dental Medicine
Abstract: The uterus is the organ from which numerous epithelial and mesenchymal tumours originate, some of which arise many difficulties when it comes to differential diagnosis. Immunohistochemistry is an important part of the differential diagnosis between endometrial versus endocervical adenocarcinoma, as well as in identifying precursor lesions. Microscopically the two locations present different histopathological varieties. Within our study we analysed the histological characters and immunohistochemical profiles of the endometrioid type of cancer. In the hereby study, the immunohistochemical marking was made using the following monoclonal antibodies: anti – vimentin, anti-estrogenic receptor and progesteronic anti receptor.
Keywords: adenocarcinoma, endometrium, endocervix, vimentin, ER/PR
References: Soslow R.A., Isacson C., Diagnostic immune-histochemistry of the female genital tract, în: Dabbs DJ: Diagnostic Immunohistochemistry, Churchill Livingstone, Philadelphia: 486-516, 2002.
Soslow R.A., Isacson C., Zaloudek C., Immuno-histopathology of the female genital tract In: Dabbs D, Diagnostic immunohistochemestry, ED DJ Dabbs second edi Churchill Livingstone Elsevier, 2006.
Sternberg S. S., Diagnostic Surgical Pathology, Raven Press, 1994, vol. 2.
Frandes D.C., Contributii la corelatiile morfo-fiziologice la nivel placentar in prematuritate si tulburari de dezvoltare, 2003.
McCluggage W.G., Recent advances in immune-histochemistry in gynaecological pathology, Histopathology.; 40(4):309-26, 2002.
McCluggage W.G., Sumathi V.P., McBride H.A., Patterson A., A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin, and estrogen receptor, aids the distinction between primary endometrial and endocervical adenocarcinomas. Int J Gynecol Pathol 21:11-15, 2002.
*Correspondence: Adriana Radu, Faculty of Medicine, Pharmacy and Dental Medicine,”Vasile Goldiş” Western University, Arad,310396, no. 94-96 Revolutiei Bd., Arad, Romania, E-mail: medicina@uvvg.ro