Potential effects of pharmaceuticals and their residues in aquatic environment

Potential effects of pharmaceuticals and their residues in aquatic environment

This is an automatically generated default intro template – please do not edit.


General information


Title: Potential effects of pharmaceuticals and their residues in aquatic environment
Meta keywords:
Meta description:

Images information


Images path absolute: /home/studia/public_html/v15/images/stories/com_form2content/p3/f186
Images path relative: com_form2content/p3/f186
Thumbs path absolute:
Thumbs path relative:

Fields information


Article_Title: Potential effects of pharmaceuticals and their residues in aquatic environment
Authors: Zsuzsanna J. Sándor, Zsuzsanna Gy. Papp, Tünde J. Kosáros, Réka Hegedűs, István Csenger
Affiliation: Research Institute for Fisheries, Aquaculture and Irrigation, Szarvas, Hungary
Abstract: The presence of pharmaceuticals, their metabolites and transformation products in the aquatic environment has become an increased concern in the last decades. The widespread presence of medicines in the environment can be explained by extensive use in medical practices and incomplete removal in Waste Water Treatment Plant. This paper provides a summary of knowledge about occurrence, fate and effects of more frequently used pharmaceuticals and some experimental data about accumulation properties of oxytetracycline in environmental and fish samples.
Keywords: pharmaceuticals, tetracycline, effects, bioaccumulation, elimination half-life
References: Boxall ABA, The environmental side effects of medication. How are human and veterinary medicines in soils and water bodies affecting human and environmental health? (viewpoint) EMBO reports 5(12), 1110-1116, 2004
Boxall ABA, Johnson P, Eshmidt EJ, Sinclaire CJ, Stutt E, Levy LS, Uptake of veterinary medicines from soils into plant. Journal of Agriculture Food Chemistry, 54, 2288-2297, 2006
Brain RA, Johnson DJ, Richards SM, Sanderson H, Sibley PK and Solomon KR, Effects of 25 pharmaceutical compounds to Lemna gibba using a seven-day static renewal test, Environmental Toxicology Chemistry, 23, 371–382, 2004
Brooks BW, Chambliss CK, Stanley JK, Ramirez A, Banks KE, Johnson RD, Lewis RJ, Determination of selected antidepressants in fish from effluent dominated stream, Environment Toxicology Chemistry 24, 464-469, 2005.
Brown JN, Paxéus N, Förlin L, Joakim Larsson DG, Variations in bio-concentration of human pharmaceuticals from sewage effluents into fish blood plasma Environmental Toxicology and Pharmacology, 24, 3, 267-274, 2007.
Bushman F, Conjugation, transposition and antibiotic resistance. Lateral DNA transfer, Mechanism and consequences. Cold Spring Halbor, NY: Cold Spring Halbor Laboratory Press, 27-72, 2002.
Capone DG, Weston DP, Miller V, Shoemaker C, Antibacterial residues in marine sediments and invertebrates following chemotherapy in aquaculture. Aquaculture 145, 55-75, 1996
Casas C, Anderson EC, Ojo KK, Keith I, Whelan D, Rainnie D, Roberts MC, Characterization of pRAS1-like plasmids from atypical North American psychrophilic Aeromonas salmonicida, FEMS Microbiological Letters 242, 1, 59-63, 2005.
Colborn T, Dumanoski D and Peterson J, Our stolen future: Are we threatening our fertility, intelligence and survival? – A scientific detective story. NEW York, NY: Dutton, Penguin Books VSA, 1996.
Cleuvers M, Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen, and acetylsalicylic acid, Ecotoxicology Environmental Safety, 59, 309-315, 2004
Daughton CG, Chemicals from Pharmaceuticals and Personal Care Product. In Water: Science and Issues, E. Julius Dasch (ed.) New York: Macmillan Reference USA, 158-164, 2003
Delépée R, Pouliquen H, Le Bris H, The bryophyte Fontinalis antipyretica Hedw. bio-accumulates oxytetracycline, flumequine, and oxolinic acid in the freshwater environment. Science Total Environment 322, 243-253, 2004
Dietrich DR, Prietz A, Fish embryotoxicity and teratogenicity of pharmaceuticals, detergents and pesticides regularly detected in sewage treatment plant effluents and surface waters, Toxicologist 48 (1-S), 151 1999
Dietrich S, Ploessl F, Bracher F, Laforsch C, Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in Daphnia magna – A multigenerational study, Chemosphere, 79, 60-66, 2010
Dodds EC and W Lawson, Molecular structure in relation to oestrogenic activity. Compounds without a phenanthrene nucleus, Proceedings of the Royal Society, London B., 125, 222- 232, 1938
Fent K, Weston AA and Caminada D, Ecotoxicology of human pharmaceuticals, Aquatic Toxicology, 76,122–159, 2006
Ferrari B, Paxeus N, Lo Giudice R, Pollio A and Garric J, Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac, Ecotoxicological Environment Safety, 55, (3), 359–370, 2003
Ferrari B, Mons R, Vollat B, Fraysse B, Paxeus N, Lo Giudice R, Pollio A and Garric J, Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?, Environmental Toxicology Chemistry, 23, 5, 1344–1354, 2004
Fuhrman JA, Marine viruses and their biogeochemical and ecological effect, Nature, 399, 6736541-548, 1999.
Han S, Choi K, Kim J, Ji K, Kim S, Ahn B, Yun J, Choi K, Kim JS, Zhang X, Giesy JP, Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magma and Moina macrocopa. Aquatic Toxicology, in press, 2010
Hong H Na, Kim H Na, Park KS, Lee SK and Gu MB :Analysis of the effects diclofenac has on Japanese medaka (Oryzias latipes) using realtime PCR, Chemosphere 67, 11, 2115-2121, 2007
Hanson ML, Knapp CW, Graham DW, Field assessment of oxytetracycline exposure to the freshwater macrophytes Egeria densa Planch. and Ceratophyllum demersum L., Environmental Pollution, 141, 3, 434-442, 2006
Jjemba PK, The potential impact of veterinary and human therapeutic agents in manure and biosolids on plants grown on arable land: a review, Agriculture, Ecosystems & Environment, 93, 1-3, 267-278, 2002
Jones OAH, Voulvoulis N, Lester JN, Aquatic environmental assessment of the top 25 English prescription pharmaceuticals, Water Research, 36, 5013-5022, 2002
Karci A and Balcioglu I A, Investigation of the tetracycline, sulphonamide, and fluoroquinolone antimicrobial compounds in animal manure and agricultural soils in Turkey, Science and Total Environment, 407, 16, 4652-4664, 2009
Kumar K, Gupta SC, Baidoo SK, Chander Y and Rosen CJ, Antibiotic uptake by plants from soil fertilized with animal manure, Journal of Environmental Quality, 34, 2082–2085, 2005
Lalumera GM, Calamari D, Galli P, Castiglioni S, Crosa G, Fanelli R. Preliminary investigations on the environmental occurrence and effects of antibiotics used in aquaculture in Italy, Chemosphere 54, 661-668, 2004
Maia PP, Rath S, Felix GRR, Determination of oxytetracycline in tomatoes by HPLC, using fluorescence detection, Food Chemistry, 109, 1, 212-218, 2008.
Migliore L, Cozzolino S, Fiori M, Phytotoxicity to and uptake of flumequine used in intensive aquaculture on the aquatic weed, Lythrum salicaria L. Chemosphere, 40, 7, 741-750, 2000
Minh TB, Leung HW, Loi IH, Chan WH, So MK, Mao JQ, Choi D, Lam JCW, Zheng G, Martin M, Lee JHW,. Lam PKS, Richardson BJ, Antibiotics in the Hong Kong metropolitan area: Ubiquitous distribution and fate in Victoria Harbour, Marine Pollution Bulletin, 58, 7, 1052-1062, 2009.
Pouliquen H, Delépée R, Thorin C, Haury J, Larhantec-Verdier M, Morvan ML, Le Bris H; Comparison of water, sediment, and plants for the monitoring of antibiotics: A case study on river dedicated to fish farming, Environmental Toxicology and Chemistry, 28, 3, 496-502, 2009
Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA, Shivaprasad HL, Ahmed S, Chaudhry MJI, Arshad M, Mahmood S, Ali A. and Khan AA, Diclofenac residues as the cause of vulture population decline in Pakistan, Nature 427,6975, 630–633, 2004
Rhodes G, Huys G, Swings J, McGann P, Hiney M, Smith P, Pickup RW, Distribution of oxytetracycline resistance plasmids between aeromonads in hospital and aquaculture environments: implication of Tn1722 in dissemination of the tetracycline resistance determinant tet A., Applied Environment Microbiology, 66, 9, 3883- 3890, 2000.
Schwaiger J, Ferling H, Mallow U, Wintermayr H and Negele RD, Toxic effects of the nonsteroidal anti-inflammatory drug diclofenac part I: Histopathological alterations and bioaccumulation in rainbow trout, Aquatic Toxicology, 68, 141–150, 2004
Záray Gy, 2006: Az analitikai kémia néhány környezettudományi kihívása. Challenges of analytical chemistry generated by environmental sciences, Magyar Kémiai Folyóirat, 112, 1, 5-8, 2004
Webb SF, A data based perspective on the environmental risk assessment of human pharmaceuticals II –aquatic risk characterisation. in: Kümmerer, K. (Ed.), Pharmaceuticals in the environment. Sources, fate, effects and risks, Springer-Verlag Berlin, Heidelberg, New York, 203–219, 2001
Read_full_article: pdf/22-2012/22-2-2012/SU22-2-2012-Sandor.pdf
Correspondence:

Read full article
Article Title: Potential effects of pharmaceuticals and their residues in aquatic environment
Authors: Zsuzsanna J. Sándor, Zsuzsanna Gy. Papp, Tünde J. Kosáros, Réka Hegedűs, István Csenger
Affiliation: Research Institute for Fisheries, Aquaculture and Irrigation, Szarvas, Hungary
Abstract: The presence of pharmaceuticals, their metabolites and transformation products in the aquatic environment has become an increased concern in the last decades. The widespread presence of medicines in the environment can be explained by extensive use in medical practices and incomplete removal in Waste Water Treatment Plant. This paper provides a summary of knowledge about occurrence, fate and effects of more frequently used pharmaceuticals and some experimental data about accumulation properties of oxytetracycline in environmental and fish samples.
Keywords: pharmaceuticals, tetracycline, effects, bioaccumulation, elimination half-life
References: Boxall ABA, The environmental side effects of medication. How are human and veterinary medicines in soils and water bodies affecting human and environmental health? (viewpoint) EMBO reports 5(12), 1110-1116, 2004
Boxall ABA, Johnson P, Eshmidt EJ, Sinclaire CJ, Stutt E, Levy LS, Uptake of veterinary medicines from soils into plant. Journal of Agriculture Food Chemistry, 54, 2288-2297, 2006
Brain RA, Johnson DJ, Richards SM, Sanderson H, Sibley PK and Solomon KR, Effects of 25 pharmaceutical compounds to Lemna gibba using a seven-day static renewal test, Environmental
Toxicology Chemistry, 23, 371–382, 2004
Brooks BW, Chambliss CK, Stanley JK, Ramirez A, Banks KE, Johnson RD, Lewis RJ, Determination of selected antidepressants in fish from effluent dominated stream, Environment Toxicology Chemistry 24, 464-469, 2005.
Brown JN, Paxéus N, Förlin L, Joakim Larsson DG, Variations in bio-concentration of human pharmaceuticals from sewage effluents into fish blood plasma Environmental Toxicology and Pharmacology, 24, 3, 267-274, 2007.
Bushman F, Conjugation, transposition and antibiotic resistance. Lateral DNA transfer, Mechanism and consequences. Cold Spring Halbor, NY: Cold Spring Halbor Laboratory Press, 27-72, 2002.
Capone DG, Weston DP, Miller V, Shoemaker C, Antibacterial residues in marine sediments and invertebrates following chemotherapy in aquaculture. Aquaculture 145, 55-75, 1996
Casas C, Anderson EC, Ojo KK, Keith I, Whelan D, Rainnie D, Roberts MC, Characterization of pRAS1-like plasmids from atypical North American psychrophilic Aeromonas salmonicida, FEMS Microbiological Letters 242, 1, 59-63, 2005.
Colborn T, Dumanoski D and Peterson J, Our stolen future: Are we threatening our fertility, intelligence and survival? – A scientific detective story. NEW York, NY: Dutton, Penguin Books VSA, 1996.
Cleuvers M, Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen, and acetylsalicylic acid, Ecotoxicology Environmental Safety, 59, 309-315, 2004
Daughton CG, Chemicals from Pharmaceuticals and Personal Care Product. In Water: Science and Issues, E. Julius Dasch (ed.) New York: Macmillan Reference USA, 158-164, 2003
Delépée R, Pouliquen H, Le Bris H, The bryophyte Fontinalis antipyretica Hedw. bio-accumulates oxytetracycline, flumequine, and oxolinic acid in the freshwater environment. Science Total Environment 322, 243-253, 2004
Dietrich DR, Prietz A, Fish embryotoxicity and teratogenicity of pharmaceuticals, detergents and pesticides regularly detected in sewage treatment plant effluents and surface waters, Toxicologist 48 (1-S), 151 1999
Dietrich S, Ploessl F, Bracher F, Laforsch C, Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in Daphnia magna – A multigenerational study, Chemosphere, 79, 60-66, 2010
Dodds EC and W Lawson, Molecular structure in relation to oestrogenic activity. Compounds without a phenanthrene nucleus, Proceedings of the Royal Society, London B., 125, 222- 232, 1938
Fent K, Weston AA and Caminada D, Ecotoxicology of human pharmaceuticals, Aquatic Toxicology, 76,122–159, 2006
Ferrari B, Paxeus N, Lo Giudice R, Pollio A and Garric J, Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac, Ecotoxicological Environment Safety, 55, (3), 359–370, 2003
Ferrari B, Mons R, Vollat B, Fraysse B, Paxeus N, Lo Giudice R, Pollio A and Garric J, Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?, Environmental Toxicology Chemistry, 23, 5, 1344–1354, 2004
Fuhrman JA, Marine viruses and their biogeochemical and ecological effect, Nature, 399, 6736541-548, 1999.
Han S, Choi K, Kim J, Ji K, Kim S, Ahn B, Yun J, Choi K, Kim JS, Zhang X, Giesy JP, Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magma and Moina macrocopa. Aquatic Toxicology, in press, 2010
Hong H Na, Kim H Na, Park KS, Lee SK and Gu MB :Analysis of the effects diclofenac has on Japanese medaka (Oryzias latipes) using realtime PCR, Chemosphere 67, 11, 2115-2121, 2007
Hanson ML, Knapp CW, Graham DW, Field assessment of oxytetracycline exposure to the freshwater macrophytes Egeria densa Planch. and Ceratophyllum demersum L., Environmental Pollution, 141, 3, 434-442, 2006
Jjemba PK, The potential impact of veterinary and human therapeutic agents in manure and biosolids on plants grown on arable land: a review, Agriculture, Ecosystems & Environment, 93, 1-3, 267-278, 2002
Jones OAH, Voulvoulis N, Lester JN, Aquatic environmental assessment of the top 25 English prescription pharmaceuticals, Water Research, 36, 5013-5022, 2002
Karci A and Balcioglu I A, Investigation of the tetracycline, sulphonamide, and fluoroquinolone antimicrobial compounds in animal manure and agricultural soils in Turkey, Science and Total Environment, 407, 16, 4652-4664, 2009
Kumar K, Gupta SC, Baidoo SK, Chander Y and Rosen CJ, Antibiotic uptake by plants from soil fertilized with animal manure, Journal of Environmental Quality, 34, 2082–2085, 2005
Lalumera GM, Calamari D, Galli P, Castiglioni S, Crosa G, Fanelli R. Preliminary investigations on the environmental occurrence and effects of antibiotics used in aquaculture in Italy, Chemosphere 54, 661-668, 2004
Maia PP, Rath S, Felix GRR, Determination of oxytetracycline in tomatoes by HPLC, using fluorescence detection, Food Chemistry, 109, 1, 212-218, 2008.
Migliore L, Cozzolino S, Fiori M, Phytotoxicity to and uptake of flumequine used in intensive aquaculture on the aquatic weed, Lythrum salicaria L. Chemosphere, 40, 7, 741-750, 2000
Minh TB, Leung HW, Loi IH, Chan WH, So MK, Mao JQ, Choi D, Lam JCW, Zheng G, Martin M, Lee JHW,. Lam PKS, Richardson BJ, Antibiotics in the Hong Kong metropolitan area: Ubiquitous distribution and fate in Victoria Harbour, Marine Pollution Bulletin, 58, 7, 1052-1062, 2009.
Pouliquen H, Delépée R, Thorin C, Haury J, Larhantec-Verdier M, Morvan ML, Le Bris H; Comparison of water, sediment, and plants for the monitoring of antibiotics: A case study on river dedicated to fish farming, Environmental Toxicology and Chemistry, 28, 3, 496-502, 2009
Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA, Shivaprasad HL, Ahmed S, Chaudhry MJI, Arshad M, Mahmood S, Ali A. and Khan AA, Diclofenac residues as the cause of vulture population decline in Pakistan, Nature 427,6975, 630–633, 2004
Rhodes G, Huys G, Swings J, McGann P, Hiney M, Smith P, Pickup RW, Distribution of oxytetracycline resistance plasmids between aeromonads in hospital and aquaculture environments: implication of Tn1722 in dissemination of the tetracycline resistance determinant tet A., Applied Environment Microbiology, 66, 9, 3883- 3890, 2000.
Schwaiger J, Ferling H, Mallow U, Wintermayr H and Negele RD, Toxic effects of the nonsteroidal anti-inflammatory drug diclofenac part I: Histopathological alterations and bioaccumulation in rainbow trout, Aquatic Toxicology, 68, 141–150, 2004
Záray Gy, 2006: Az analitikai kémia néhány környezettudományi kihívása. Challenges of analytical chemistry generated by environmental sciences, Magyar Kémiai Folyóirat, 112, 1, 5-8, 2004
Webb SF, A data based perspective on the environmental risk assessment of human pharmaceuticals II –aquatic risk characterisation. in: Kümmerer, K. (Ed.), Pharmaceuticals in the environment. Sources, fate, effects and risks, Springer-Verlag Berlin, Heidelberg, New York, 203–219, 2001
*Correspondence: