The polymers influence on the swelling index of nebivolol 10 mg mucoadhesive buccal tablets

November 17, 2014

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Article Title:	The polymers influence on the swelling index of nebivolol 10 mg mucoadhesive buccal tablets
Authors:	Khalaf. Z., Ardelean S., Dumitrescu I.-B., Ardelean M, Lupuleasa D.
Affiliation:	1 „Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest 2 „Vasile Goldiș” Western University of Arad, Faculty of Pharmacy, Arad, Romania
Abstract:	The paper presents the results of our study regarding the influence on swelling index for controlled released mucoadhesive buccal tablets of nebivolol. In this aim there were analyzed three different polymers in various ratios in order to increase the delivery of the drug: hydroxipropylmethylcelullose (HPMC) -types K4M and K15M and Carbomer 940. The profiles studied for these formulations, 4 with each of the polymers showed greater values for HPMC.
Keywords:	nebivolol hydrocloride, swelling index, mucoadhesive buccal tablets, polymers.
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*Correspondence:	Ion-Bogdan Dumitrescu, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia St., Bucharest, Romania. Tel: +40-(21)-3180747, email: ibdumitrescu@umf.ro