Formulation and characterization of biocompatible microemulsions for topical administration of sodium diclofenac

November 17, 2014

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Article Title:	Formulation and characterization of biocompatible microemulsions for topical administration of sodium diclofenac
Authors:	Cojocaru V., Ailiesei I., Orbeşteanu A.-M., Cinteză O.-L.
Affiliation:	Faculty of Pharmacy, „Carol Davila” University of Medicine and Pharmacy, Bucharest Department of Physical Chemistry, University of Bucharest
Abstract:	The purpose of this study was to develop microemulsion-based drug vehicles for topical administration of sodium diclofenac (SD), using Tween 80 and 1-octanol as surfactant and cosurfactant, respectively. Three commonly pharmaceutical oils (isopropyl myristate, arachis oil and canola oil) were investigated as oil phases. Microemulsion existence region was identified through the construction of the pseudoternary phase diagrams, using water titration method. The prepared microemulsions were evaluated regarding their transparency/translucency, optical birefringence, electrical conductivity, viscosity, pH and stability. The isopropyl myristate-based systems showed a slightly higher area of microemulsion existence and permitted the formation of microemulsions at lower concentrations of surfactants. The effect of added active substance on the stability of microemulsions was also evaluated for 1% SD (w/w).
Keywords:	topical microemulsion, sodium diclofenac, viscosity, electrical conductivity, optical birefringence
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*Correspondence:	Victor Cojocaru, „Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, no. 6 Traian Vuia St., 020956, Sector 2, Bucharest, Romania, email: victor.cojocaru@umf.ro

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