Effects of Hypericum perforatum and Hypericum maculatum extracts on the rats’ brain intoxicated with alcohol

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Article Title:	Effects of Hypericum perforatum and Hypericum maculatum extracts on the rats’ brain intoxicated with alcohol
Authors:	Ioana Roman, Constantin Puică, Mihai Cristescu
Affiliation:	Department of Experimental Biology and Biochemistry, Institute of Biological Research Cluj-Napoca, Branch of National Institute of Research and Development for Biological Sciences, Bucharest, Romania University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania
Abstract:	The aim of experiment was to study the effects of two different alcoholic extracts, containing 0.3% and 0.15% hypericin, of two different species of Hypericum (H. perforatum L. and H. maculatum Crantz) on some morphological parameters in rats’ brain. Extracts were administered for 10 days in white female Wistar rats, weighing 200 ± 20 g. that were previously intoxicated with alcohol (6g/kg body) for 35 days. We found that the administration of Hypericum perforatum and Hypericum maculatum alcoholic extracts in the two experimental variants of dose (0.3 and 0.15 % hypericin) had sedative effects, animals manifesting somnolence, especially consecutively with a dose administration of 0.3% of hypericin.
Keywords:	rats, brain, alcohol intoxication, hypericum perforatum, hypericum maculatum
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*Correspondence:	Ioana Roman, Institute of Biological Research Cluj-Napoca, Department of Experimental Biology and Biochemistry, 48 Republicii Str, 400015, Cluj-Napoca, Romania, Tel. +40-(0264)-591238, Fax. +40-(0264)-591238, email: ioana.roman@icbcluj.ro