The effect of Vaccinium vitis idaea L. extract administration on kidney structure and function in alcohol intoxicated rats

November 17, 2014

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Article Title:	The effect of Vaccinium vitis idaea L. extract administration on kidney structure and function in alcohol intoxicated rats
Authors:	Roman I., Puică C., Toma V.A.
Affiliation:	1Department of Experimental Biology and Biochemistry, Institute of Biological Research Cluj-Napoca, Branch of National Institute of Research and Development for Biological Sciences, Bucharest, Romania
Abstract:	The study was focused on the assessment of the protector potential of 1:1 hydro-alcoholic extract of Vaccinium vits idaea L (lingonberry) (in a dose of 200 mg/100 g bw d.s.) On some kidney morphological aspects and biochemical blood parameters (urea and creatinine) relating to impairment of kidney function in white Wistar rats due to a subchronic alcohol intoxication.Extracts were administered for 15 days in white female Wistar rats, weighing 150 ± 10 g, or at the same time with alcohol 500 (6g/kg body). We found that single administration of vegetable extract of lingonberry not caused toxic effects on the kidney function, while treating animals with lingonberry extract had beneficial effects in preventing and protecting parameters of kidney function taken into study (urea and creatinine), in terms of alcoholic intoxication.
Keywords:	alcohol intoxication, lingonberry extract, rats, kidney
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*Correspondence:	Ioana Roman, Institute of Biological Research Cluj-Napoca, Department of Experimental Biology and Biochemistry, 48 Republicii Str, 400015, Cluj-Napoca, Romania, Tel.+40-(0264)-591238, Fax. +40-(0264)-591238, email: ioana.roman@icbcluj.ro

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