Matrix tablets with metoprolol salts based on natural hydrophilic colloids such as alginates, carraggens and xanthan gum

March 21, 2013

Matrix tablets with metoprolol salts based on natural hydrophilic colloids such as alginates, carraggens and xanthan gum

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Title:	Matrix tablets with metoprolol salts based on natural hydrophilic colloids such as alginates, carraggens and xanthan gum
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Article_Title:	Matrix tablets with metoprolol salts based on natural hydrophilic colloids such as alginates, carraggens and xanthan gum
Authors:	Morouj Daas, Corina Toderescu, Ioana Olaru, Dumitru Lupuleasa
Affiliation:	University of Medicine and Pharmacy ,,Carol Davila” Bucharest Departament Pharmeceutical Technology and Biopharmacy
Abstract:	Hydrophilic matrix tablets comprising metoprolol salts (succinate and tartrate). and hydrophilic natural colloids such as carrageens, alginates and xanthan, were obtained by direct compression on a single station tablet press, in order to obtain a modified release of the drug. The influence of the natural polymer, the polymer ratio on the compresibility of the tablet and their influence on in vitro release of the active substance, were studied. The tablets were evaluated for weight uniformity, drug content, hardness and friability. The study demonstrated that it is possible to fabricate modified release tablets of metoprolol salts hydrophylic natural colloids such as carrageens, alginates and xanthan gum and the drug release was found to be dependent on the ratio and type of the matrixing agents.
Keywords:	alginates, carrageens, drug release, hidroxypropyl methyl cellulose (HPMC), hydrophylic natural colloids, metoprolol ((+)-1-(isopropyl) amino)-3-[p-(2-methoxyethyl)]-2-propanolol) succinate or tartric salt and xanthan gum.
References:	1. Afrodita Doina Mărculescu, M.Tudoraşcu, Lumi niţa Balău ,,Study of ketoprohene release fromhydrophylic matrices based on xanthan gum”, Farmacia, vol. LII, nr. 4 pp. 53-59, 2004 2. Camelia Balasz, S.E. Leucuţa ,,The influence of some hydrophylic polymers upon diltiazem hidrochloride dissolution from matrix dosage forms formulations” Farmacia vol. LVI, nr.3, pp 244-253 2006 3. M. Bamba, F. Puisievx, J.P. Marty and J.T. Cartensen, Release mechanism in gel forming sustained release formulation, Int. J. Pharm, 2: 307-315 (1979). 4. M.C. Bonferoni, S. Rossi, M. Tamayo, J. L. Pedraz, A. Dominiguz-Gil, On the employment of l-carrageenan II. l-Carrageenan and hydroxypropylmethylcellulose mextures. J.Control.Release. 30: 175-182 (1994) 5. G.Dănilă ,,Beta blocants-drugs: present and perspectives” Farmacia 4, pp 47-62, 1998 6. Dhopeshwarkar V., Zatz J.L. ,,Evaluation of xanthan gum in the preparation of sustained release matrix tablets” Drug Dev. Ind. Pharm. 19, pp 999-1017, 1993 7. M. C. Gohel, A.F. Amin, K.V.Patel and M.K.Panchal, Studies in release behavior of diltiazem HCl from matrix tablets containing (hidroxypropyl) methylcellulose and xanthan gum, Boll. Chim. Farmac. 141:21-28 (2002) 8. Gozman-Pop Felicia, Bojiţă M., Bratu I., Borodi Gh. ,,Studiul complecşilor de incluziune ai atenololului şi metoprololului tatrat cu beta-ciclodextrina” Farmacia vol LI, nr.5, pp 76-85, 2003 9. E. Mendell, Controlled release metoprolol oral composition containing heteropolysaccharides and a method for the preparation thereof, U.S. Patent US5399362, April 25, 1995 10. N. Mulye, Inamdar Kavita, Sustained release tablet containing hydrocolloid and cellulose ether, US Patent US6416786, July 9, 2002 11. J. Sujjaareevath, D. L. Munday, P. J. Cox and K. A. Khan, Relation ship between swelling, erosion and drug release from hydrophilic natural gum minimatrix formulation, Eur. J. Pharm. Sci. 6:207-208 (1998) 12. C.W. Vendruscolo, I.F. Andreazza, J.L. Ganter, Xanthan and galactomannan (form M. scabrella) matrix tablets for oral controlled delivery of theophyline, Int. J. Pharm. 296: 1-11 (2005). 13. M.M. Talukdar, A. Michael, P. Rombaut and R. Kinget, Comparative study on xanthan and hydroxypropyl methylcellulose as matrices for controlled- release drug delivery, Int. J. Pharm. 129:233-241 (1996) 14. Wise, Donald L., Handbook of Pharmaceutical controlled Release, New-York MarcelDekker Inc. pp 155-179, 183-205, 255-267, 2000 15. ***European Pharmacopeia 5th edition, vol.2
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Article Title:	Matrix tablets with metoprolol salts based on natural hydrophilic colloids such as alginates, carraggens and xanthan gum
Authors:	Morouj Daas, Corina Toderescu, Ioana Olaru, Dumitru Lupuleasa
Affiliation:	University of Medicine and Pharmacy ,,Carol Davila” Bucharest Departament Pharmeceutical Technology and Biopharmacy
Abstract:	Hydrophilic matrix tablets comprising metoprolol salts (succinate and tartrate). and hydrophilic natural colloids such as carrageens, alginates and xanthan, were obtained by direct compression on a single station tablet press, in order to obtain a modified release of the drug. The influence of the natural polymer, the polymer ratio on the compresibility of the tablet and their influence on in vitro release of the active substance, were studied. The tablets were evaluated for weight uniformity, drug content, hardness and friability. The study demonstrated that it is possible to fabricate modified release tablets of metoprolol salts hydrophylic natural colloids such as carrageens, alginates and xanthan gum and the drug release was found to be dependent on the ratio and type of the matrixing agents.
Keywords:	alginates, carrageens, drug release, hidroxypropyl methyl cellulose (HPMC), hydrophylic natural colloids, metoprolol ((+)-1-(isopropyl) amino)-3-[p-(2-methoxyethyl)]-2-propanolol) succinate or tartric salt and xanthan gum.
References:	1. Afrodita Doina Mărculescu, M.Tudoraşcu, Lumi niţa Balău ,,Study of ketoprohene release fromhydrophylic matrices based on xanthan gum”, Farmacia, vol. LII, nr. 4 pp. 53-59, 2004 2. Camelia Balasz, S.E. Leucuţa ,,The influence of some hydrophylic polymers upon diltiazem hidrochloride dissolution from matrix dosage forms formulations” Farmacia vol. LVI, nr.3, pp 244-253 2006 3. M. Bamba, F. Puisievx, J.P. Marty and J.T. Cartensen, Release mechanism in gel forming sustained release formulation, Int. J. Pharm, 2: 307-315 (1979). 4. M.C. Bonferoni, S. Rossi, M. Tamayo, J. L. Pedraz, A. Dominiguz-Gil, On the employment of l-carrageenan II. l-Carrageenan and hydroxypropylmethylcellulose mextures. J.Control.Release. 30: 175-182 (1994) 5. G.Dănilă ,,Beta blocants-drugs: present and perspectives” Farmacia 4, pp 47-62, 1998 6. Dhopeshwarkar V., Zatz J.L. ,,Evaluation of xanthan gum in the preparation of sustained release matrix tablets” Drug Dev. Ind. Pharm. 19, pp 999-1017, 1993 7. M. C. Gohel, A.F. Amin, K.V.Patel and M.K.Panchal, Studies in release behavior of diltiazem HCl from matrix tablets containing (hidroxypropyl) methylcellulose and xanthan gum, Boll. Chim. Farmac. 141:21-28 (2002) 8. Gozman-Pop Felicia, Bojiţă M., Bratu I., Borodi Gh. ,,Studiul complecşilor de incluziune ai atenololului şi metoprololului tatrat cu beta-ciclodextrina” Farmacia vol LI, nr.5, pp 76-85, 2003 9. E. Mendell, Controlled release metoprolol oral composition containing heteropolysaccharides and a method for the preparation thereof, U.S. Patent US5399362, April 25, 1995 10. N. Mulye, Inamdar Kavita, Sustained release tablet containing hydrocolloid and cellulose ether, US Patent US6416786, July 9, 2002 11. J. Sujjaareevath, D. L. Munday, P. J. Cox and K. A. Khan, Relation ship between swelling, erosion and drug release from hydrophilic natural gum minimatrix formulation, Eur. J. Pharm. Sci. 6:207-208 (1998) 12. C.W. Vendruscolo, I.F. Andreazza, J.L. Ganter, Xanthan and galactomannan (form M. scabrella) matrix tablets for oral controlled delivery of theophyline, Int. J. Pharm. 296: 1-11 (2005). 13. M.M. Talukdar, A. Michael, P. Rombaut and R. Kinget, Comparative study on xanthan and hydroxypropyl methylcellulose as matrices for controlled- release drug delivery, Int. J. Pharm. 129: 233-241 (1996) 14. Wise, Donald L., Handbook of Pharmaceutical controlled Release, New-York MarcelDekker Inc. pp 155-179, 183-205, 255-267, 2000 15. ***European Pharmacopeia 5th edition, vol.2
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