Tilia tomentosa foliar bud extract: Phytochemical analysis and dermatological testing

Authors: Camelia PEEV¹, Cristina DEHELEAN¹, Diana ANTAL¹, Ştefana FEFLEA¹, Laura OLARIU², Claudia TOMA³

Affiliation: ¹ University of Medicine and Pharmacy “Victor Babeş”, Timişoara, Romania; ² S.C. Biotehnos S.A. Bucureşti – Otopeni, Romania; ³ “Vasile Goldiș” Western University, Faculty of Medicine, Pharmacy and Dental Medicine, Arad, Romania

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ABSTRACT. Foliar buds are a new category of vegetal products which are used in gemmotherapy. The present study has highlighted the average content of water, carotenoides, total polyphenols, chlorophyll, vegetal hormones and hemolytic saponins, contained in the foliar buds of Silver Lime or Silver Linden. The study consists of a comparative bio-test on Lepidium sativum and of the evaluation of the balance between efficacy and noxiousness of a topic Linden bud preparation, on human skin by determining the level of hydration and that of transepidermal water loss (TEWL).  The chemical analysis of the Linden bud extracts conducted to the following results: total polyphenols – 380 mg/100 g buds; the detected phyto-hormones were: auxin, cytokinin and gibberellin; the total hemolytic saponin concentration was 5.2%. According to the comparative test of Lepidium sativum, the sample showed an inhibition rate of 83.33%. The balanced composition of the hydro-glycero-alcoholic extract of Linden foliar buds, along with the positive results of the dermatologic hydration analysis, and with the possible anti-proliferative activity, conduct to a more clear hypothesis that these extracts may become ingredients in chemo-protective and anti-aging preparations.

Keywords: Silver Linden, buds, cosmetic, hydration, vegetal extracts